DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease

DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patie...

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Bibliographic Details
Published in:Scientific reports 2012-12, Vol.2 (1), p.954-954, Article 954
Main Authors: Lin, Xiangmin, Cook, Travis J., Zabetian, Cyrus P., Leverenz, James B., Peskind, Elaine R., Hu, Shu-Ching, Cain, Kevin C., Pan, Catherine, Edgar, John Scott, Goodlett, David R., Racette, Brad A., Checkoway, Harvey, Montine, Thomas J., Shi, Min, Zhang, Jing
Format: Article
Language:English
Subjects:
631/378/1689/1718
631/45/475
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Aged
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Biomarkers
Biomarkers - blood
Blood
Blood levels
Blotting, Western
Cell death
Cerebrospinal fluid
Electrophoresis, Gel, Two-Dimensional
Female
Humanities and Social Sciences
Humans
Intracellular Signaling Peptides and Proteins - blood
Isoforms
Male
Middle Aged
Movement disorders
multidisciplinary
Neurodegenerative diseases
Oncogene Proteins - blood
Oxidative stress
PARK7 protein
Parkinson Disease - blood
Parkinson Disease - diagnosis
Parkinson's disease
Post-translation
Protein Deglycase DJ-1
Protein Isoforms - blood
Protein Processing, Post-Translational
Science
Speech disorders
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Summary:DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep00954