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Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats
The objective was to investigate the antiurolithiatic and antioxidant activity of ethanolic extract of Hordeum vulgare seeds (EHV) on ethylene glycol-induced urolithiasis in Wistar albino rats. Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water...
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| Published in: | Indian journal of pharmacology 2012-11, Vol.44 (6), p.672-677 |
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| container_end_page | 677 |
| container_issue | 6 |
| container_start_page | 672 |
| container_title | Indian journal of pharmacology |
| container_volume | 44 |
| creator | Shah, Jignesh G Patel, Bharat G Patel, Sandip B Patel, Ravindra K |
| description | The objective was to investigate the antiurolithiatic and antioxidant activity of ethanolic extract of Hordeum vulgare seeds (EHV) on ethylene glycol-induced urolithiasis in Wistar albino rats.
Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.
The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.
These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent. |
| doi_str_mv | 10.4103/0253-7613.103237 |
| format | article |
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Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.
The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.
These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.103237</identifier><identifier>PMID: 23248392</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Barley ; Calculi, Urinary ; Catalase - metabolism ; Development and progression ; Ethylene Glycol ; Female ; Health aspects ; Hordeum ; Male ; Malondialdehyde - metabolism ; Materia medica, Vegetable ; Medical research ; Medicine, Ayurvedic ; Mice ; Natural products ; Pharmacology ; Physiological aspects ; Phytotherapy ; Plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Seeds ; Superoxide Dismutase - metabolism ; Urolithiasis - chemically induced ; Urolithiasis - metabolism ; Urolithiasis - pathology ; Urolithiasis - therapy</subject><ispartof>Indian journal of pharmacology, 2012-11, Vol.44 (6), p.672-677</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Nov/Dec 2012</rights><rights>Copyright: © Indian Journal of Pharmacology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-cdff272b147e238e47c07e8c1a6cbfeab99f94de35677b99b3e1718756e526d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1220820233?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23248392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Jignesh G</creatorcontrib><creatorcontrib>Patel, Bharat G</creatorcontrib><creatorcontrib>Patel, Sandip B</creatorcontrib><creatorcontrib>Patel, Ravindra K</creatorcontrib><title>Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>The objective was to investigate the antiurolithiatic and antioxidant activity of ethanolic extract of Hordeum vulgare seeds (EHV) on ethylene glycol-induced urolithiasis in Wistar albino rats.
Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.
The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.
These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Barley</subject><subject>Calculi, Urinary</subject><subject>Catalase - metabolism</subject><subject>Development and progression</subject><subject>Ethylene Glycol</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hordeum</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Materia medica, Vegetable</subject><subject>Medical research</subject><subject>Medicine, Ayurvedic</subject><subject>Mice</subject><subject>Natural products</subject><subject>Pharmacology</subject><subject>Physiological aspects</subject><subject>Phytotherapy</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seeds</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Urolithiasis - chemically induced</subject><subject>Urolithiasis - metabolism</subject><subject>Urolithiasis - pathology</subject><subject>Urolithiasis - therapy</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptUk1r3DAUFKWh2aa991QEPXurD9uyLoUlJE0h0Et6FrL07FWwpVSSl-6_j5ZNtw0sQjxGb2YkPQahT5Ssa0r4V8IaXomW8nVBjIs3aEWl7CouGvoWrU7tS_Q-pUdScC3bd-iScVZ3XLIVihuf3RLD5PLW6ewM1t6WnV3442ypWJvsdi7vcRjwXYgWlhnvlmnUEXACsAkHjyFv9xN4wOO0N2GqnLeLAYtPzskl7DyOOqcP6GLQU4KPL_UK_bq9ebi-q-5_fv9xvbmvTMNkrowdBiZYT2sBjHdQC0MEdIbq1vQD6F7KQdYWeNMKUUDPgQraiaaFhrWW8iv07ej7tPQzWAM-Rz2pp-hmHfcqaKded7zbqjHsFG8YryUpBl9eDGL4vUDK6jEs0Zc3K8oY6RhhnP9jjXoC5fwQipmZXTJqw4lsm1a2B1Z1hjWWkZWbg4fBleNX_PUZflkWZmfOCshRYGJIKcJw-igl6hAWdUiDOqRBHcNSJJ__H9BJ8Dcd_BmN3rtd</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Shah, Jignesh G</creator><creator>Patel, Bharat G</creator><creator>Patel, Sandip B</creator><creator>Patel, Ravindra K</creator><general>Medknow Publications and Media Pvt. 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Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.
The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.
These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>23248392</pmid><doi>10.4103/0253-7613.103237</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0253-7613 |
| ispartof | Indian journal of pharmacology, 2012-11, Vol.44 (6), p.672-677 |
| issn | 0253-7613 1998-3751 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3523490 |
| source | PubMed (Medline); Publicly Available Content Database |
| subjects | Animals Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Barley Calculi, Urinary Catalase - metabolism Development and progression Ethylene Glycol Female Health aspects Hordeum Male Malondialdehyde - metabolism Materia medica, Vegetable Medical research Medicine, Ayurvedic Mice Natural products Pharmacology Physiological aspects Phytotherapy Plant extracts Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Seeds Superoxide Dismutase - metabolism Urolithiasis - chemically induced Urolithiasis - metabolism Urolithiasis - pathology Urolithiasis - therapy |
| title | Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats |
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