RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells

Resistance to 5-fluorouracil (5-FU) in patients with gastric cancer is a serious therapeutic problem and major efforts are underway to understand the underlying mechanisms. We have previously identified RhoGDI2 as a contributor to 5-FU resistance in colon cancer cells using 2D electrophoresis and ma...

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Bibliographic Details
Published in:Oncology letters 2013-01, Vol.5 (1), p.255-260
Main Authors: ZHENG, ZHONG, HE, XIANG-YI, LI, JIAN-FANG, YU, BEI-QIN, CHEN, XUE-HUA, JI, JUN, ZHANG, JIA-NIAN, GU, QIN-LONG, ZHU, ZHENG-GANG, LIU, BING-YA
Format: Article
Language:English
Subjects:
5-fluorouracil resistance
Apoptosis
Bladder cancer
Breast cancer
Cell culture
Cell cycle
Chemotherapy
Colorectal cancer
Drug dosages
Gastric cancer
Laboratories
Lymphoma
Oncology
RhoGDI2
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Summary:Resistance to 5-fluorouracil (5-FU) in patients with gastric cancer is a serious therapeutic problem and major efforts are underway to understand the underlying mechanisms. We have previously identified RhoGDI2 as a contributor to 5-FU resistance in colon cancer cells using 2D electrophoresis and mass spectrometry and the current study aimed to further investigate this role. The expression of RhoGDI2 in seven gastric cancer cell lines was positively correlated with resistance to 5-FU. Lower 5-FU sensitivity of isolated tumor cells from patients with gastric cancer was also associated with higher RhoGDI2 expression. Ectopic expression of RhoGDI2 in gastric cancer cells increased the resistance to 5-FU and reverted low dose 5-FU-induced G2/M phase arrest without affecting the population of sub-G1 cells. Overall, these findings suggest that RhoGDI2 is associated with 5-FU resistance and is a potential therapeutic target for enhancing chemotherapy efficacy in gastric cancer.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2012.949