Use of Recombinant Factor VIIa in a Pediatric Patient With Initial Presentation of Refractory Acute Immune Thrombocytopenic Purpura and Severe Bleeding

Severe bleeding in acute immune thrombocytopenic purpura (ITP) is rare but can cause significant complications to the patient. Here we report the case of a pediatric patient with acute ITP and hematuria refractory to anti-D immune globulin, high dose intravenous immunoglobulin G, and high dose stero...

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Bibliographic Details
Published in:The journal of pediatric pharmacology and therapeutics 2012-07, Vol.17 (3), p.274-280
Main Authors: Gurion, Reut, Siu, Anita, Weiss, Aaron R, Masterson, Margaret
Format: Article
Language:English
Subjects:
Clinical Investigation
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Summary:Severe bleeding in acute immune thrombocytopenic purpura (ITP) is rare but can cause significant complications to the patient. Here we report the case of a pediatric patient with acute ITP and hematuria refractory to anti-D immune globulin, high dose intravenous immunoglobulin G, and high dose steroids. Her hematuria was successfully treated with recombinant factor VIIa (rFVIIa). While further investigation on the use of rFVIIa in ITP is warranted, this case report contributes to the pediatric literature for its use during the course of an initial presentation of ITP with hemorrhagic complications.
ISSN:1551-6776
1551-6776
DOI:10.5863/1551-6776-17.3.274