Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis

Mammalian (or mechanistic) target of rapamycin (mTOR) regulates a wide range of cellular and developmental processes by coordinating signaling responses to mitogens, nutrients, and various stresses. Over the last decade, mTOR has emerged as a master regulator of skeletal myogenesis, controlling mult...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 2012-12, Vol.287 (52), p.43928-43935
Main Authors: Ge, Yejing, Chen, Jie
Format: Article
Language:English
Subjects:
Animals
Humans
Minireviews
mTOR
mTOR Complex (mTORC)
Muscle Development - physiology
Muscle Proteins - genetics
Muscle Proteins - metabolism
Muscle, Skeletal - enzymology
Myogenesis
Signal Transduction - physiology
Signaling
Skeletal Muscle
TOR Serine-Threonine Kinases - genetics
TOR Serine-Threonine Kinases - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mammalian (or mechanistic) target of rapamycin (mTOR) regulates a wide range of cellular and developmental processes by coordinating signaling responses to mitogens, nutrients, and various stresses. Over the last decade, mTOR has emerged as a master regulator of skeletal myogenesis, controlling multiple stages of the myofiber formation process. In this minireview, we present an emerging view of the signaling network underlying mTOR regulation of myogenesis, which contrasts with the well established mechanisms in the regulation of cell and muscle growth. Current questions for future studies are also highlighted.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R112.406942