Genomic Association Analysis Identifies Multiple Loci Influencing Antihypertensive Response to an Angiotensin II Receptor Blocker

To identify genes influencing blood pressure response to an angiotensin II receptor blocker, single nucleotide polymorphisms identified by genome-wide association analysis of the response to candesartan were validated by opposite direction associations with the response to a thiazide diuretic, hydro...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-06, Vol.59 (6), p.1204-1211
Main Authors: Turner, Stephen T, Bailey, Kent R, Schwartz, Gary L, Chapman, Arlene B, Chai, High Seng, Boerwinkle, Eric
Format: Article
Language:English
Subjects:
Adult
African Americans - genetics
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Antihypertensive agents
Arterial hypertension. Arterial hypotension
Benzimidazoles - therapeutic use
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Blood Pressure - genetics
Cardiology. Vascular system
Cardiovascular system
Case-Control Studies
Chi-Square Distribution
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 16 - genetics
Diuretics - therapeutic use
Drug Administration Schedule
Epithelial Sodium Channels - genetics
European Continental Ancestry Group - genetics
Female
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Genotype
Humans
Hydrochlorothiazide - therapeutic use
Hypertension - drug therapy
Hypertension - ethnology
Hypertension - genetics
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Polymorphism, Single Nucleotide
Receptors, G-Protein-Coupled - genetics
Renin-Angiotensin System - genetics
Tetrazoles - therapeutic use
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Summary:To identify genes influencing blood pressure response to an angiotensin II receptor blocker, single nucleotide polymorphisms identified by genome-wide association analysis of the response to candesartan were validated by opposite direction associations with the response to a thiazide diuretic, hydrochlorothiazide. We sampled 198 white and 193 blacks with primary hypertension from opposite tertiles of the race-sex–specific distributions of age-adjusted diastolic blood pressure response to candesartan. There were 285 polymorphisms associated with the response to candesartan at P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYP.0b013e31825b30f8