Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model

The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properti...

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Published in:Malaria Research and Treatment 2012, Vol.2012 (2012), p.25-29
Main Authors: Zamani, Zahra, Tafreshi, Alireza Sadeghi, Nahrevanian, Hossein, Lame-Rad, Behzad, Pourfallah, Fatemeh, Eslamifar, Hossein, Sadeghi, Sedigheh, Vahabi, Farideh, Iravani, Ayda, Arjmand, Mohammad
Format: Article
Language:English
Subjects:
Life Sciences
Microbiology and Parasitology
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Summary:The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P
ISSN:2044-4362
2090-8075
2044-4362
DOI:10.1155/2012/381724