LKB1 and AMP‐activated protein kinase: regulators of cell polarity

Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polar...

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Bibliographic Details
Published in:Genes to cells : devoted to molecular & cellular mechanisms 2012-09, Vol.17 (9), p.737-747
Main Authors: Nakano, Atsushi, Takashima, Seiji
Format: Article
Language:English
Subjects:
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - physiology
Animals
Caenorhabditis elegans - enzymology
Caenorhabditis elegans - physiology
Cell Movement
Cell Polarity
Cell Shape
Drosophila - enzymology
Drosophila - genetics
Drosophila - physiology
Drosophila Proteins - genetics
Drosophila Proteins - physiology
Gene Expression Regulation, Enzymologic
Mammals - genetics
Mammals - physiology
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - physiology
Microtubules - physiology
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Phosphorylation
Protein Kinases - genetics
Protein Kinases - physiology
Review
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Summary:Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.
ISSN:1356-9597
1365-2443
DOI:10.1111/j.1365-2443.2012.01629.x