Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target

Highlights ► Glaucoma involves degeneration of the retinal ganglion cell projection. ► Deficits in retinal axon transport to the superior colliculus (SC) are retinotopic. ► BDNF increases retinotopically in the SC with transport loss prior to synapse loss. ► Astrocytes become hypertrophic in the tra...

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Bibliographic Details
Published in:Neuroscience 2013-01, Vol.229, p.55-70
Main Authors: Crish, S.D, Dapper, J.D, MacNamee, S.E, Balaram, P, Sidorova, T.N, Lambert, W.S, Calkins, D.J
Format: Article
Language:English
Subjects:
Animals
astrocytes
Astrocytes - metabolism
axonal transport
Axonal Transport - physiology
Biological and medical sciences
brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Disease Models, Animal
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
glaucoma
Glaucoma - genetics
Glaucoma - metabolism
Mice
neurodegeneration
Neurology
Optic Nerve Diseases - genetics
Optic Nerve Diseases - metabolism
Rats
Retinal Ganglion Cells - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Superior Colliculi - metabolism
superior colliculus
Synapses - metabolism
Vertebrates: nervous system and sense organs
Visual Pathways - metabolism
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Summary:Highlights ► Glaucoma involves degeneration of the retinal ganglion cell projection. ► Deficits in retinal axon transport to the superior colliculus (SC) are retinotopic. ► BDNF increases retinotopically in the SC with transport loss prior to synapse loss. ► Astrocytes become hypertrophic in the transport lesion. ► Astrocytes may sequester BDNF for focal re-release.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.10.069