Heterologous Production of 4‑O‑Demethylbarbamide, a Marine Cyanobacterial Natural Product

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2012-12, Vol.14 (23), p.5824-5827
Main Authors: Kim, Eun Ji, Lee, Jong Hyun, Choi, Hyukjae, Pereira, Alban R, Ban, Yeon Hee, Yoo, Young Ji, Kim, Eunji, Park, Je Won, Sherman, David H, Gerwick, William H, Yoon, Yeo Joon
Format: Article
Language:English
Subjects:
Biological Products - chemistry
Biological Products - isolation & purification
chemical reactions
chemical structure
Cyanobacteria - chemistry
heterologous gene expression
Marine Biology
Molecular Structure
Moorea producens
Multigene Family
organic compounds
Stereoisomerism
Streptomyces - chemistry
Streptomyces venezuelae
Thiazoles - chemistry
Thiazoles - isolation & purification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/ol302575h