Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas

The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of unders...

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Bibliographic Details
Published in:Development and psychopathology 2012-11, Vol.24 (4), p.1427-1442
Main Authors: Naumova, Oksana Yu, Palejev, Dean, Vlasova, Natalia V., Lee, Maria, Rychkov, Sergei Yu, Babich, Olga N., M. Vaccarino, Flora, Grigorenko, Elena L.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Aging - genetics
Aging - metabolism
Brain
Cell cycle
Female
Frontal Lobe - metabolism
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Humans
Morphology
Neocortex - metabolism
Neurological disorders
Oligonucleotide Array Sequence Analysis
Population
Sequence Analysis, RNA
Temporal Lobe - metabolism
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Summary:The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system.
ISSN:0954-5794
1469-2198
DOI:10.1017/S0954579412000818