Tailoring 3D Single-Walled Carbon Nanotubes Anchored to Indium Tin Oxide for Natural Cellular Uptake and Intracellular Sensing

The ability to monitor intracellular events in real time is paramount to advancing fundamental biological and clinical science. We present the first demonstration of a direct interface of vertically aligned single-walled carbon nanotubes (VASWCNTs) with eukaryotic cells, RAW 264.7 mouse macrophage c...

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Bibliographic Details
Published in:Nano letters 2013-01, Vol.13 (1), p.1-8
Main Authors: Rawson, F. J, Yeung, C. L, Jackson, S. K, Mendes, P. M
Format: Article
Language:English
Subjects:
Animals
Biosensing Techniques
Biotechnology
Cell Line
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Indium tin oxide
Letter
Macrophages - metabolism
Materials science
Mice
Microscopy, Atomic Force
Monitors
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Nanotubes
Nanotubes, Carbon
Photoelectron Spectroscopy
Physics
Platforms
Real time
Single wall carbon nanotubes
Three dimensional
Tin Compounds - chemistry
Uptakes
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Summary:The ability to monitor intracellular events in real time is paramount to advancing fundamental biological and clinical science. We present the first demonstration of a direct interface of vertically aligned single-walled carbon nanotubes (VASWCNTs) with eukaryotic cells, RAW 264.7 mouse macrophage cell line. The cells were cultured on indium tin oxide with VASWCNTs. VASWCNTs entered the cells naturally without application of any external force and were shown to sense the intracellular presence of a redox active moiety, methylene blue. The technology developed provides an alluring platform to enable electrochemical study of an intracellular environment.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl203780d