The role of the tumor microenvironment in regulating angiogenesis

The tumor-associated stroma has been shown to play a significant role in cancer formation. Paracrine signaling interactions between epithelial tumor cells and stromal cells are a key component in the transformation and proliferation of tumors in several organs. Whereas the intracellular signaling pa...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2012-12, Vol.2 (12), p.a006676-a006676
Main Author: Watnick, Randolph S
Format: Article
Language:English
Subjects:
Bone Marrow Cells - physiology
Cell Communication - physiology
Cell Transformation, Neoplastic - pathology
Fibroblast Growth Factor 2 - physiology
Fibroblasts - physiology
Hormones - physiology
Humans
Matrix Metalloproteinases - physiology
Neoplasm Invasiveness - physiopathology
Neoplasms - blood supply
Neoplasms - pathology
Neoplasms - physiopathology
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - physiopathology
Receptors, Cytoplasmic and Nuclear - physiology
Stromal Cells - physiology
Tumor Microenvironment - physiology
Vascular Endothelial Growth Factor A - physiology
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Summary:The tumor-associated stroma has been shown to play a significant role in cancer formation. Paracrine signaling interactions between epithelial tumor cells and stromal cells are a key component in the transformation and proliferation of tumors in several organs. Whereas the intracellular signaling pathways regulating the expression of several pro- and antiangiogenic proteins have been well characterized in human cancer cells, the intercellular signaling that takes place between tumor cells and the surrounding tumor-associated stroma has not been as extensively studied with regard to the regulation of angiogenesis. In this chapter we define the key players in the regulation of angiogenesis and examine how their expression is regulated in the tumor-associated stroma. The resulting analysis is often seemingly paradoxical, underscoring the complexity of intercellular signaling within tumors and the need to better understand the environmental context underlying these signaling mechanisms.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a006676