Data fusion in metabolomic cancer diagnostics

We have recently shown that fluorescence spectroscopy of plasma samples has promising abilities regarding early detection of colorectal cancer. In the present paper, these results were further developed by combining fluorescence with the biomarkers, CEA and TIMP-1 and traditional metabolomic measure...

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Bibliographic Details
Published in:Metabolomics 2013-02, Vol.9 (1), p.3-8
Main Authors: Bro, Rasmus, Nielsen, Hans Jørgen, Savorani, Francesco, Kjeldahl, Karin, Christensen, Ib Jarle, Brünner, Nils, Lawaetz, Anders Juul
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Life Sciences
Molecular Medicine
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Summary:We have recently shown that fluorescence spectroscopy of plasma samples has promising abilities regarding early detection of colorectal cancer. In the present paper, these results were further developed by combining fluorescence with the biomarkers, CEA and TIMP-1 and traditional metabolomic measurements in the form of 1 H NMR spectroscopy. The results indicate that using an extensive profile established by combining such measurements together with the biomarkers is better than using single markers.
ISSN:1573-3882
1573-3890
DOI:10.1007/s11306-012-0446-0