Effect of Menses on Clearance of Y-Chromosome in Vaginal Fluid: Implications for a Biomarker of Recent Sexual Activity

Self-reported sexual behaviors are subject to bias. We previously developed a polymerase chain reaction for the detection of Y-chromosome sequences in vaginal fluid as a potential biomarker of recent sexual activity. In this study, we found menses results in lower Y-chromosome concentrations but wit...

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Bibliographic Details
Published in:Sexually transmitted diseases 2010-01, Vol.37 (1), p.1-4
Main Authors: Brotman, Rebecca M., Melendez, Johan H., Smith, Tukisa D., Galai, Noya, Zenilman, Jonathan M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers
Case-Control Studies
Chromosomes
Chromosomes, Human, Y - physiology
Coitus
Epidemiology. Vaccinations
Female
General aspects
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
Medical sciences
Menstruation
Menstruation - physiology
Polymerase Chain Reaction
Sensitivity and Specificity
Sexual behavior
Sexually Transmitted Diseases - prevention & control
Studies
Vagina - physiology
Vaginal Smears
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Summary:Self-reported sexual behaviors are subject to bias. We previously developed a polymerase chain reaction for the detection of Y-chromosome sequences in vaginal fluid as a potential biomarker of recent sexual activity. In this study, we found menses results in lower Y-chromosome concentrations but with similar decay patterns as non-menstrual samples.
ISSN:0148-5717
1537-4521
DOI:10.1097/olq.0b013e3181b5f15d