A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. We included 178 young patients with lone AF and the first episode before the age of 40 y...

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Bibliographic Details
Published in:Journal of negative results in biomedicine 2013-01, Vol.12 (1), p.1-1, Article 1
Main Authors: Henningsen, Kristoffer M A, Olesen, Morten S, Sajadieh, Golnaz, Haunsoe, Stig, Svendsen, Jesper H
Format: Article
Language:English
Subjects:
Adipokines - blood
Adult
Age of Onset
Atrial fibrillation
Atrial Fibrillation - genetics
Brief Report
Case-Control Studies
Chitinase-3-Like Protein 1
Female
Genetic aspects
Genetic Predisposition to Disease
Humans
Lectins - blood
Male
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Single nucleotide polymorphisms
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Summary:Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
ISSN:1477-5751
1477-5751
DOI:10.1186/1477-5751-12-1