Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset

Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We...

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Bibliographic Details
Published in:Scientific reports 2013-01, Vol.3 (1), p.1141, Article 1141
Main Authors: Di Rienzo, Carmine, Jacchetti, Emanuela, Cardarelli, Francesco, Bizzarri, Ranieri, Beltram, Fabio, Cecchini, Marco
Format: Article
Language:English
Subjects:
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Arteriosclerosis
Atherogenesis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Cell Shape
Cytology
Cytoskeleton
Endothelial cells
Genetic transformation
Human Umbilical Vein Endothelial Cells
Humanities and Social Sciences
Humans
Investigations
Localization
Low density lipoprotein
LOX-1 protein
Mechanotransduction
Mechanotransduction, Cellular
Morphology
multidisciplinary
Nanostructures - chemistry
Nanotechnology
Oligomerization
Physiology
Reactive Oxygen Species - metabolism
Scavenger Receptors, Class E - genetics
Scavenger Receptors, Class E - metabolism
Science
Topography
Transfection
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Summary:Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01141