Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset

Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2013-01, Vol.3 (1), p.1141, Article 1141
Main Authors: Di Rienzo, Carmine, Jacchetti, Emanuela, Cardarelli, Francesco, Bizzarri, Ranieri, Beltram, Fabio, Cecchini, Marco
Format: Article
Language:English
Subjects:
631/57/2282
639/301/54/2295
639/301/54/993
639/925/352/1061
Arteriosclerosis
Atherogenesis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Cell Shape
Cytology
Cytoskeleton
Endothelial cells
Genetic transformation
Human Umbilical Vein Endothelial Cells
Humanities and Social Sciences
Humans
Investigations
Localization
Low density lipoprotein
LOX-1 protein
Mechanotransduction
Mechanotransduction, Cellular
Morphology
multidisciplinary
Nanostructures - chemistry
Nanotechnology
Oligomerization
Physiology
Reactive Oxygen Species - metabolism
Scavenger Receptors, Class E - genetics
Scavenger Receptors, Class E - metabolism
Science
Topography
Transfection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683
cites cdi_FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683
container_end_page
container_issue 1
container_start_page 1141
container_title Scientific reports
container_volume 3
creator Di Rienzo, Carmine
Jacchetti, Emanuela
Cardarelli, Francesco
Bizzarri, Ranieri
Beltram, Fabio
Cecchini, Marco
description Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.
doi_str_mv 10.1038/srep01141
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3555090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1897431603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683</originalsourceid><addsrcrecordid>eNplkUtrGzEUhUVJqUPiRf5AEXSVwjR6jkddFIrJo2DIpoHshKy541EYS1NJdvG_r4xT4xAtJKHzce7RvQhdUfKNEt7cpAgjoVTQD-icESErxhk7O7lP0DSlF1KWZEpQ9QlNGOdSKinOETz5LbjB-RVePD5XFEewMOYQsfMZ4jiYHf7rco-98SGHMayiGfvdd7wG2--fovGp3djsgsfGt9jkHmJIdtjvLuHgE-RL9LEzQ4Lp63mBnu5uf88fqsXj_a_5z0VlBW9yJSTw2spaiZnpBFESGCedqClv6k4tZ7xWnNeNpQ1tm1YqSpg00LKOLutlEfgF-nHwHTfLNbQWfMk36DG6tYk7HYzTbxXver0KW13aIYkixeDLq0EMfzaQsn4Jm-hLZk0bNROc1oQX6vpA2fLH0v_uWIESvR-KPg6lsJ9PIx3J_yMowNcDkIrkVxBPSr5z-wf9v5ep</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1897431603</pqid></control><display><type>article</type><title>Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset</title><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Di Rienzo, Carmine ; Jacchetti, Emanuela ; Cardarelli, Francesco ; Bizzarri, Ranieri ; Beltram, Fabio ; Cecchini, Marco</creator><creatorcontrib>Di Rienzo, Carmine ; Jacchetti, Emanuela ; Cardarelli, Francesco ; Bizzarri, Ranieri ; Beltram, Fabio ; Cecchini, Marco</creatorcontrib><description>Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep01141</identifier><identifier>PMID: 23355954</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/57/2282 ; 639/301/54/2295 ; 639/301/54/993 ; 639/925/352/1061 ; Arteriosclerosis ; Atherogenesis ; Atherosclerosis ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Cell Shape ; Cytology ; Cytoskeleton ; Endothelial cells ; Genetic transformation ; Human Umbilical Vein Endothelial Cells ; Humanities and Social Sciences ; Humans ; Investigations ; Localization ; Low density lipoprotein ; LOX-1 protein ; Mechanotransduction ; Mechanotransduction, Cellular ; Morphology ; multidisciplinary ; Nanostructures - chemistry ; Nanotechnology ; Oligomerization ; Physiology ; Reactive Oxygen Species - metabolism ; Scavenger Receptors, Class E - genetics ; Scavenger Receptors, Class E - metabolism ; Science ; Topography ; Transfection</subject><ispartof>Scientific reports, 2013-01, Vol.3 (1), p.1141, Article 1141</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Jan 2013</rights><rights>Copyright © 2013, Macmillan Publishers Limited. All rights reserved 2013 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683</citedby><cites>FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1897431603/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1897431603?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23355954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Rienzo, Carmine</creatorcontrib><creatorcontrib>Jacchetti, Emanuela</creatorcontrib><creatorcontrib>Cardarelli, Francesco</creatorcontrib><creatorcontrib>Bizzarri, Ranieri</creatorcontrib><creatorcontrib>Beltram, Fabio</creatorcontrib><creatorcontrib>Cecchini, Marco</creatorcontrib><title>Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.</description><subject>631/57/2282</subject><subject>639/301/54/2295</subject><subject>639/301/54/993</subject><subject>639/925/352/1061</subject><subject>Arteriosclerosis</subject><subject>Atherogenesis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - pathology</subject><subject>Cell Shape</subject><subject>Cytology</subject><subject>Cytoskeleton</subject><subject>Endothelial cells</subject><subject>Genetic transformation</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Investigations</subject><subject>Localization</subject><subject>Low density lipoprotein</subject><subject>LOX-1 protein</subject><subject>Mechanotransduction</subject><subject>Mechanotransduction, Cellular</subject><subject>Morphology</subject><subject>multidisciplinary</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology</subject><subject>Oligomerization</subject><subject>Physiology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Scavenger Receptors, Class E - genetics</subject><subject>Scavenger Receptors, Class E - metabolism</subject><subject>Science</subject><subject>Topography</subject><subject>Transfection</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplkUtrGzEUhUVJqUPiRf5AEXSVwjR6jkddFIrJo2DIpoHshKy541EYS1NJdvG_r4xT4xAtJKHzce7RvQhdUfKNEt7cpAgjoVTQD-icESErxhk7O7lP0DSlF1KWZEpQ9QlNGOdSKinOETz5LbjB-RVePD5XFEewMOYQsfMZ4jiYHf7rco-98SGHMayiGfvdd7wG2--fovGp3djsgsfGt9jkHmJIdtjvLuHgE-RL9LEzQ4Lp63mBnu5uf88fqsXj_a_5z0VlBW9yJSTw2spaiZnpBFESGCedqClv6k4tZ7xWnNeNpQ1tm1YqSpg00LKOLutlEfgF-nHwHTfLNbQWfMk36DG6tYk7HYzTbxXver0KW13aIYkixeDLq0EMfzaQsn4Jm-hLZk0bNROc1oQX6vpA2fLH0v_uWIESvR-KPg6lsJ9PIx3J_yMowNcDkIrkVxBPSr5z-wf9v5ep</recordid><startdate>20130125</startdate><enddate>20130125</enddate><creator>Di Rienzo, Carmine</creator><creator>Jacchetti, Emanuela</creator><creator>Cardarelli, Francesco</creator><creator>Bizzarri, Ranieri</creator><creator>Beltram, Fabio</creator><creator>Cecchini, Marco</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20130125</creationdate><title>Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset</title><author>Di Rienzo, Carmine ; Jacchetti, Emanuela ; Cardarelli, Francesco ; Bizzarri, Ranieri ; Beltram, Fabio ; Cecchini, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/57/2282</topic><topic>639/301/54/2295</topic><topic>639/301/54/993</topic><topic>639/925/352/1061</topic><topic>Arteriosclerosis</topic><topic>Atherogenesis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - metabolism</topic><topic>Atherosclerosis - pathology</topic><topic>Cell Shape</topic><topic>Cytology</topic><topic>Cytoskeleton</topic><topic>Endothelial cells</topic><topic>Genetic transformation</topic><topic>Human Umbilical Vein Endothelial Cells</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Investigations</topic><topic>Localization</topic><topic>Low density lipoprotein</topic><topic>LOX-1 protein</topic><topic>Mechanotransduction</topic><topic>Mechanotransduction, Cellular</topic><topic>Morphology</topic><topic>multidisciplinary</topic><topic>Nanostructures - chemistry</topic><topic>Nanotechnology</topic><topic>Oligomerization</topic><topic>Physiology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Scavenger Receptors, Class E - genetics</topic><topic>Scavenger Receptors, Class E - metabolism</topic><topic>Science</topic><topic>Topography</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Rienzo, Carmine</creatorcontrib><creatorcontrib>Jacchetti, Emanuela</creatorcontrib><creatorcontrib>Cardarelli, Francesco</creatorcontrib><creatorcontrib>Bizzarri, Ranieri</creatorcontrib><creatorcontrib>Beltram, Fabio</creatorcontrib><creatorcontrib>Cecchini, Marco</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Rienzo, Carmine</au><au>Jacchetti, Emanuela</au><au>Cardarelli, Francesco</au><au>Bizzarri, Ranieri</au><au>Beltram, Fabio</au><au>Cecchini, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2013-01-25</date><risdate>2013</risdate><volume>3</volume><issue>1</issue><spage>1141</spage><pages>1141-</pages><artnum>1141</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23355954</pmid><doi>10.1038/srep01141</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2045-2322
ispartof Scientific reports, 2013-01, Vol.3 (1), p.1141, Article 1141
issn 2045-2322
2045-2322
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3555090
source Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access
subjects 631/57/2282
639/301/54/2295
639/301/54/993
639/925/352/1061
Arteriosclerosis
Atherogenesis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Cell Shape
Cytology
Cytoskeleton
Endothelial cells
Genetic transformation
Human Umbilical Vein Endothelial Cells
Humanities and Social Sciences
Humans
Investigations
Localization
Low density lipoprotein
LOX-1 protein
Mechanotransduction
Mechanotransduction, Cellular
Morphology
multidisciplinary
Nanostructures - chemistry
Nanotechnology
Oligomerization
Physiology
Reactive Oxygen Species - metabolism
Scavenger Receptors, Class E - genetics
Scavenger Receptors, Class E - metabolism
Science
Topography
Transfection
title Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T22%3A29%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Unveiling%20LOX-1%20receptor%20interplay%20with%20nanotopography:%20mechanotransduction%20and%20atherosclerosis%20onset&rft.jtitle=Scientific%20reports&rft.au=Di%20Rienzo,%20Carmine&rft.date=2013-01-25&rft.volume=3&rft.issue=1&rft.spage=1141&rft.pages=1141-&rft.artnum=1141&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep01141&rft_dat=%3Cproquest_pubme%3E1897431603%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c438t-45e36c56947af4095e230f461386f9b73693368c181d8d591025aed2f1b6b3683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1897431603&rft_id=info:pmid/23355954&rfr_iscdi=true