Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues

Formalin‐fixed paraffin‐embedded (FFPE) tissue specimens comprise a potentially valuable resource for both prospective and retrospective biomarker discovery. Unlocking the proteomic profile of clinicopathological FFPE tissues is a critically essential step for annotating clinical findings and predic...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2012-04, Vol.12 (7), p.1045-1058
Main Authors: Magdeldin, Sameh, Yamamoto, Tadashi
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
FFPE
Fixation
Formaldehyde
Formalin
Fundamental and applied biological sciences. Psychology
Humans
Mice
Miscellaneous
Paraffin Embedding
Protein Stability
Proteins
Proteome
Proteome - analysis
Proteome - chemistry
Proteomics - methods
Proteomics - standards
Reproducibility of Results
Review
Reviews
Solvents - chemistry
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Description
Summary:Formalin‐fixed paraffin‐embedded (FFPE) tissue specimens comprise a potentially valuable resource for both prospective and retrospective biomarker discovery. Unlocking the proteomic profile of clinicopathological FFPE tissues is a critically essential step for annotating clinical findings and predicting biomarkers for ultimate disease prognosis and therapeutic follow‐up.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.201100550