The Minnesota Center for Twin and Family Research Genome-Wide Association Study

As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 52...

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Bibliographic Details
Published in:Twin research and human genetics 2012-12, Vol.15 (6), p.767-774
Main Authors: Miller, Michael B., Basu, Saonli, Cunningham, Julie, Eskin, Eleazar, Malone, Steven M., Oetting, William S., Schork, Nicholas, Sul, Jae Hoon, Iacono, William G., McGue, Matt
Format: Article
Language:English
Subjects:
Achievement tests
Adoption
Adoptive families
Adult
Age
Algorithms
Behavior
Behavior genetics
Child development
Consortia
Drug use
Family
Female
Follow-Up Studies
Genome-wide association studies
Genome-Wide Association Study
Genomes
Human genetics
Humans
Longitudinal studies
Male
Mental disorders
Mental health
Middle Aged
Minnesota
Parents & parenting
Participation
Personality
Polymorphism, Single Nucleotide
Quality control
Siblings
Single-nucleotide polymorphism
Socioeconomic factors
Statistical power
Substance use disorder
Twins
Variation
Young adults
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Description
Summary:As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina's Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.
ISSN:1832-4274
1839-2628
DOI:10.1017/thg.2012.62