Surgery Quality and Tumor Status Impact on Survival and Local Control of Resectable Liposarcomas of Extremities or the Trunk Wall

• Published in: Clinical orthopaedics and related research 2013-03, Vol.471 (3), p.860-870
• Main Authors: Rutkowski, Piotr, Trepka, Sławomir, Ptaszynski, Konrad, Kołodziejczyk, Milena
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Conservative Orthopedics; Disease-Free Survival; Extremities; Female; Humans; Kaplan-Meier Estimate; Liposarcoma - mortality; Liposarcoma - pathology; Liposarcoma - radiotherapy; Liposarcoma - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - prevention & control; Neoplasm Staging; Orthopedics; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Risk Factors; Soft Tissue Neoplasms - mortality; Soft Tissue Neoplasms - pathology; Soft Tissue Neoplasms - radiotherapy; Soft Tissue Neoplasms - surgery; Sports Medicine; Surgery; Surgical Orthopedics; Symposium: Highlights from the First Combined 2011 Meeting of the Musculoskeletal Tumor Society and Connective Tissue Oncology Society; Time Factors; Torso; Treatment Outcome; Tumor; Young Adult
• ISSN: 0009-921X; 1528-1132
• DOI: 10.1007/s11999-012-2592-0

Background The 5-year survival rates for localized liposarcomas reportedly vary from 75% to 91% with histologic grade as the most important prognostic factor. However, it is unclear which other factors, including the initial surgery quality and recurrent tumors, influence survival in localized liposarcomas (LPS). Questions/Purposes We analyzed factors (including AJCC staging system) influencing survival and local control of resectable LPS of the extremities/trunk wall and the impact of surgery quality and tumor status and type of disease recurrences according to pathological subtype. Methods We retrospectively reviewed 181 patients with localized LPS: 110 were treated for primary tumors, 50 for recurrent tumors, and 21 for wide scar resection after unplanned nonradical resection. We determined survival rates and examined factors influencing survival. The minimum followup was 4 months (median, 52 months; range, 4–168 months). Results Five-year disease-specific (DSS), disease-free (DFS), and local relapse-free survival (LRFS) rates were: 80%, 58%, and 75%, respectively. Five-year local relapse-free survival rates for primary versus clinically recurrent tumor versus scar after nonradical resection were: 86.1%, 52.1%, and 73.3%, respectively. The following were independent negative prognostic factors for DSS (AJCC Stage ≥ IIb), DFS (Grade 3; clinical recurrence; skin infiltration), and LRFS (clinical recurrence; R1 resection). An unplanned excision, although influencing local relapse-free survival, had no impact on disease-specific survival (calculated from date of first excision 5-year rate of 80%, considering impact of combined treatment of clinical recurrence/scar). Conclusions We confirmed the value of AJCC staging for predicting disease-specific survival in extremity/trunk wall LPS. Radical reresection of scar after nonradical primary tumor resection (+ radiotherapy) seems to improve disease-free and local relapse-free survival in liposarcomas. Patients with unplanned excision can be cured when referred to a sarcoma unit. Level of Evidence Level IV, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence