The Gut Microbiome: A New Frontier in Autism Research

The human gut harbors a complex community of microbes that profoundly influence many aspects of growth and development, including development of the nervous system. Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we review f...

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Bibliographic Details
Published in:Current psychiatry reports 2013-02, Vol.15 (2), p.337-337, Article 337
Main Authors: Mulle, Jennifer G., Sharp, William G., Cubells, Joseph F.
Format: Article
Language:English
Subjects:
Animals
Autism
Autistic Disorder - microbiology
Central Nervous System - growth & development
Central Nervous System - microbiology
Digestive system
Feeding Behavior
Gastrointestinal Tract - microbiology
Genetic Disorders (JF Cubells and EB Binder
Humans
Medicine
Medicine & Public Health
Microbiota
Psychiatry
Section Editors
Topical Collection on Genetic Disorders
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Summary:The human gut harbors a complex community of microbes that profoundly influence many aspects of growth and development, including development of the nervous system. Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we review fundamental emerging data on the human gut microbiome, with a focus on potential interactions between the microbiome and autism spectrum disorders (ASD) and consider research on atypical patterns of feeding and nutrition in ASD and how they might interact with the microbiome. Finally we selectively survey results from studies in rodents on the impact of the microbiome on neurobehavioral development. The evidence reviewed here suggests that a deeper understanding of the gut microbiome could open up new avenues of research on ASD, including potential novel treatment strategies.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-012-0337-0