Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections

Highlights ► Pyocyanin (PYO) is a redox-active virulence factor of Pseudomonas aeruginosa . ► PYO promotes inflammatory responses by imposing oxidative stress on host cells. ► PYO is required for full virulence in several models of P. aeruginosa infection. ► PYO levels were correlated with declining...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2013-02, Vol.21 (2), p.73-81
Main Authors: Rada, Balázs, Leto, Thomas L
Format: Article
Language:English
Subjects:
animal models
cell respiration
cystic fibrosis
Cystic Fibrosis - metabolism
Cystic Fibrosis - microbiology
electron transfer
energy metabolism
epithelium
gene expression
Gene Expression Regulation
Host-Pathogen Interactions
Humans
Internal Medicine
Mucins - biosynthesis
Oxidation-Reduction
patients
Pseudomonas
Pseudomonas aeruginosa
Pseudomonas aeruginosa - metabolism
Pseudomonas aeruginosa - pathogenicity
Pseudomonas Infections - genetics
Pseudomonas Infections - metabolism
pyocyanin
Pyocyanine - metabolism
redox
respiratory
respiratory mucosa
Respiratory Mucosa - metabolism
Respiratory Mucosa - microbiology
toxins
virulence
Virulence Factors
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Summary:Highlights ► Pyocyanin (PYO) is a redox-active virulence factor of Pseudomonas aeruginosa . ► PYO promotes inflammatory responses by imposing oxidative stress on host cells. ► PYO is required for full virulence in several models of P. aeruginosa infection. ► PYO levels were correlated with declining lung function in cystic fibrosis.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2012.10.004