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Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections
Highlights ► Pyocyanin (PYO) is a redox-active virulence factor of Pseudomonas aeruginosa . ► PYO promotes inflammatory responses by imposing oxidative stress on host cells. ► PYO is required for full virulence in several models of P. aeruginosa infection. ► PYO levels were correlated with declining...
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| Published in: | Trends in microbiology (Regular ed.) 2013-02, Vol.21 (2), p.73-81 |
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| Main Authors: | , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c629t-eece258bd7319a87950493136c1502975e14d26837ea221952c18dedf6a574ce3 |
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| cites | cdi_FETCH-LOGICAL-c629t-eece258bd7319a87950493136c1502975e14d26837ea221952c18dedf6a574ce3 |
| container_end_page | 81 |
| container_issue | 2 |
| container_start_page | 73 |
| container_title | Trends in microbiology (Regular ed.) |
| container_volume | 21 |
| creator | Rada, Balázs Leto, Thomas L |
| description | Highlights ► Pyocyanin (PYO) is a redox-active virulence factor of Pseudomonas aeruginosa . ► PYO promotes inflammatory responses by imposing oxidative stress on host cells. ► PYO is required for full virulence in several models of P. aeruginosa infection. ► PYO levels were correlated with declining lung function in cystic fibrosis. |
| doi_str_mv | 10.1016/j.tim.2012.10.004 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0966-842X |
| ispartof | Trends in microbiology (Regular ed.), 2013-02, Vol.21 (2), p.73-81 |
| issn | 0966-842X 1878-4380 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3565070 |
| source | ScienceDirect Journals |
| subjects | animal models cell respiration cystic fibrosis Cystic Fibrosis - metabolism Cystic Fibrosis - microbiology electron transfer energy metabolism epithelium gene expression Gene Expression Regulation Host-Pathogen Interactions Humans Internal Medicine Mucins - biosynthesis Oxidation-Reduction patients Pseudomonas Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - genetics Pseudomonas Infections - metabolism pyocyanin Pyocyanine - metabolism redox respiratory respiratory mucosa Respiratory Mucosa - metabolism Respiratory Mucosa - microbiology toxins virulence Virulence Factors |
| title | Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections |
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