Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is...

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Bibliographic Details
Published in:Translational psychiatry 2013-01, Vol.3 (1), p.e210-e210
Main Authors: Mateus-Pinheiro, A, Pinto, L, Bessa, J M, Morais, M, Alves, N D, Monteiro, S, Patrício, P, Almeida, O F X, Sousa, N
Format: Article
Language:English
Subjects:
631/378/368
631/92/436
692/699/476/1414
Analysis of Variance
Animals
Antidepressive Agents - metabolism
Antidepressive Agents - pharmacology
Astrocytes - drug effects
Astrocytes - pathology
Behavior, Animal - drug effects
Behavioral Sciences
Biological Psychology
Cell Proliferation - drug effects
Conditioning (Psychology)
Depression - drug therapy
Depression - pathology
Fluoxetine - metabolism
Fluoxetine - pharmacology
Hippocampus - drug effects
Hippocampus - pathology
Imipramine - metabolism
Imipramine - pharmacology
Male
Medicine
Medicine & Public Health
Methylazoxymethanol Acetate - analogs & derivatives
Methylazoxymethanol Acetate - pharmacology
Neurogenesis - drug effects
Neurons - drug effects
Neurons - pathology
Neurosciences
Original
original-article
Pharmacotherapy
Psychiatry
Rats
Rats, Wistar
Stress, Psychological - metabolism
Stress, Psychological - pathology
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Summary:Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2012.141