An evolutionary explanation for the presence of cancer nonstem cells in neoplasms

Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor‐propagating cells, while most of the tumor is composed of cells with limited replication poten...

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Bibliographic Details
Published in:Evolutionary applications 2013-01, Vol.6 (1), p.92-101
Main Authors: Sprouffske, Kathleen, Athena Aktipis, C., Radich, Jerald P., Carroll, Martin, Nedelcu, Aurora M., Maley, Carlo C.
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cell culture
Cell division
Charitable trusts
Computer applications
Daughters
Evolution
Hypotheses
Mathematical models
Melanoma
Mutation
Original
Stem cells
Tumors
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Summary:Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor‐propagating cells, while most of the tumor is composed of cells with limited replication potential. Here, we offer an evolutionary approach to this controversy. We used several evolutionary, computational models to investigate cancer cell dynamics and conditions consistent with the stem cell hypothesis. Our models predict that if selection acts at the cell level, neoplasms should be primarily comprised of cancer stem cells, in contrast to experimental data indicating that neoplasms contain large fractions of cancer nonstem cells. We explore several solutions explaining the paradoxical existence of cancer nonstem cells in neoplasms, including the possibility that selection acts at the level of multicellular proliferative units.
ISSN:1752-4571
1752-4571
DOI:10.1111/eva.12030