The simplest explanation: passive DNA demethylation in PGCs

During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks.

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Bibliographic Details
Published in:The EMBO journal 2013-02, Vol.32 (3), p.318-321
Main Authors: Smith, Zachary D, Meissner, Alexander
Format: Article
Language:English
Subjects:
Animals
Cellular biology
Deoxyribonucleic acid
DNA
DNA Methylation - physiology
Genome - genetics
Genomic Imprinting - genetics
Genomics
Germ Cells - physiology
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Models, Biological
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Description
Summary:During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks.
ISSN:0261-4189
1460-2075
DOI:10.1038/emboj.2012.349