The simplest explanation: passive DNA demethylation in PGCs

During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks.

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Published in:The EMBO journal 2013-02, Vol.32 (3), p.318-321
Main Authors: Smith, Zachary D, Meissner, Alexander
Format: Article
Language:English
Subjects:
Animals
Cellular biology
Deoxyribonucleic acid
DNA
DNA Methylation - physiology
Genome - genetics
Genomic Imprinting - genetics
Genomics
Germ Cells - physiology
Have You Seen?
Models, Biological
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cited_by cdi_FETCH-LOGICAL-c6109-c4ba4f017fae827d5623f1a4f7d01212dbaa31d5ca5df9c16725ab3ed23dd9683
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description During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks.
doi_str_mv 10.1038/emboj.2012.349
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subjects Animals
Cellular biology
Deoxyribonucleic acid
DNA
DNA Methylation - physiology
Genome - genetics
Genomic Imprinting - genetics
Genomics
Germ Cells - physiology
Have You Seen?
Models, Biological
title The simplest explanation: passive DNA demethylation in PGCs
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