Recent advances in drug eluting stents

One of the most common medical interventions to reopen an occluded vessel is the implantation of a coronary stent. While this method of treatment is effective initially, restenosis, or the re-narrowing of the artery frequently occurs largely due to neointimal hyperplasia of smooth muscle cells. Drug...

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-01, Vol.441 (1-2), p.665-679
Main Authors: Puranik, Amey S., Dawson, Eileen R., Peppas, Nicholas A.
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis - surgery
Controlled release
Coronary Occlusion - surgery
Coronary Restenosis - prevention & control
Delayed-Action Preparations
Drug Delivery Systems
Drug eluting stent
Drug-Eluting Stents - adverse effects
Humans
Neointima - prevention & control
Restenosis
Sirolimus
Stent
Stents - adverse effects
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Summary:One of the most common medical interventions to reopen an occluded vessel is the implantation of a coronary stent. While this method of treatment is effective initially, restenosis, or the re-narrowing of the artery frequently occurs largely due to neointimal hyperplasia of smooth muscle cells. Drug eluting stents were developed in order to provide local, site-specific, controlled release of drugs that can inhibit neointima formation. By implementing a controlled release delivery system it may be possible to control the time release of the pharmacological factors and thus be able to bypass some of the critical events associated with stent hyperplasia and prevent the need for subsequent intervention. However, since the advent of first-generation drug eluting stents, long-term adverse effects have raised concerns regarding their safety. These limitations in safety and efficacy have triggered considerable research in developing biodegradable stents and more potent drug delivery systems. In this review, we shed light on the current state-of-the-art in drug eluting stents, problems related to them and highlight some of the ongoing research in this area.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.10.029