Carbon Monoxide Mediates Vasoactive Intestinal Polypeptide-Associated Nonadrenergic/Noncholinergic Neurotransmission

Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sph...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (8), p.2631-2635
Main Authors: Watkins, Crystal C., Boehning, Darren, Kaplin, Adam I., Rao, Mahil, Ferris, Christopher D., Snyder, Solomon H.
Format: Article
Language:English
Subjects:
Anal Canal - drug effects
Anal Canal - physiology
Anatomy & physiology
Animals
Anus
Biological Sciences
Carbon monoxide
Carbon Monoxide - physiology
Cyclic GMP - metabolism
Enzymes
Gastrointestinal Agents - pharmacology
Heme Oxygenase (Decyclizing) - deficiency
Heme Oxygenase (Decyclizing) - genetics
Heme Oxygenase (Decyclizing) - metabolism
Kinetics
Mice
Mice, Knockout
Myenteric plexus
Neurons
Neurotransmission
Nitric Oxide Synthase - deficiency
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type I
Peptides
Rattan work
Smooth muscle
Synaptic transmission
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Vasoactive Intestinal Peptide - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sphincter (IAS), NANC relaxation is mediated primarily by CO. Vasoactive intestinal polypeptide (VIP) has also been shown to participate in NANC relaxation throughout the intestine, including the IAS. By using a combination of pharmacology and genetic knockout of the biosynthetic enzymes for CO and NO, we show that the physiologic effects of exogenous and endogenous VIP in the IAS are mediated by HO2-synthesized CO.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0308695100