Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON‐TB Gold Assay Results

To evaluate the utility of the QuantiFERON‐TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON‐TB Gold posit...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2009-04, Vol.30 (4), p.392-395
Main Authors: Pollock, Nira R., Kashino, Suely S., Napolitano, Danielle R., Sloutsky, Alex, Joshi, Swati, Guillet, Jasmine, Wong, Michael, Nardell, Edward, Campos‐Neto, Antonio
Format: Article
Language:English
Subjects:
Adult
Antigens
Antitubercular Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Concise Communication
Cutaneous tuberculosis
Female
Human bacterial diseases
Humans
Infectious diseases
Interferon-gamma - blood
Isoniazid - therapeutic use
Latent tuberculosis
Lymphocyte Activation
Male
Medical sciences
Middle Aged
Miscellaneous
Mycobacterium
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Nursing
Occupational health services
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reagent Kits, Diagnostic
Screening tests
Skin
Skin Tests
Treatment Outcome
Tuberculin
Tuberculin - immunology
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - immunology
Tuberculosis - microbiology
Tuberculosis and atypical mycobacterial infections
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Summary:To evaluate the utility of the QuantiFERON‐TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON‐TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON‐TB Gold assay to monitor therapy.
ISSN:0899-823X
1559-6834
DOI:10.1086/596606