Loading…
Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV
While distal sensory polyneuropathy (DSP) is the most common neurological condition associated with HIV, causing nerve damage in upper and lower extremities, its impact on neuropsychological test performance is unclear. In this study, we analyzed baseline data for 278 HIV-infected participants with...
Saved in:
Published in: | Journal of the International Neuropsychological Society 2012-09, Vol.18 (5), p.898-907 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3 |
---|---|
cites | cdi_FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3 |
container_end_page | 907 |
container_issue | 5 |
container_start_page | 898 |
container_title | Journal of the International Neuropsychological Society |
container_volume | 18 |
creator | Fellows, Robert P. Byrd, Desiree A. Elliott, Kathryn Robinson-Papp, Jessica Mindt, Monica Rivera Morgello, Susan |
description | While distal sensory polyneuropathy (DSP) is the most common neurological condition associated with HIV, causing nerve damage in upper and lower extremities, its impact on neuropsychological test performance is unclear. In this study, we analyzed baseline data for 278 HIV-infected participants with comprehensive neurological and neurocognitive evaluations to examine the contribution of DSP and anatomic distribution of neuropathic signs (upper extremity or lower extremity) on standardized domain scores. We found that participants with DSP performed significantly worse in multiple domains containing timed psychomotor tests (i.e., motor, information processing speed and executive functioning). With regard to executive functioning, differences were limited to a test with a motor component (Trail Making Test, Part B). The group with clinically detectable neuropathic signs in the upper extremities and the group with signs limited to the lower extremities both performed worse in the motor domain than the group without DSP. Participants with DSP demonstrated a unique pattern of impairment limited to neuropsychological domains with timed psychomotor tests. These results suggest that caution should be used in interpretation of neuropsychological tests in patients with DSP, as some abnormalities may be exacerbated by peripheral nervous system pathology. (JINS, 2012, 19, 1–10) |
doi_str_mv | 10.1017/S1355617712000707 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3571681</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S1355617712000707</cupid><sourcerecordid>2858614091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3</originalsourceid><addsrcrecordid>eNp1kc1O3DAUhS3UCijtA7CpInXDJtTXTuxkUwlB-ZFQQYJ2a3mcmxnTxB7spChvXw8zIGjFypbPd47v0SVkH-ghUJBfb4CXpQApgVFKJZVbZBcKUedSCHiX7knOV_oO-RDjHaXAgdJtssOYqKEoy13y-8TGQXfZDbrow5Rd-25yOAa_1MNiymzMjmL0xuoBm-zBDovsx6MaJ7PwnZ9bk8y3GIfsGkPrQ6-dwUz33s1XL9G7uLadX_z6SN63uov4aXPukZ-n32-Pz_PLq7OL46PL3BQShhx4YQrE1jRQUJb6MK5nYpbmbVnDhZZQt2go1iut0qyh2BTSCE2R0Zo3fI98W-cux1mPjUE3BN2pZbC9DpPy2qrXirMLNfd_FC8liApSwMEmIPj7MZVTvY0Gu0479GNUQLmsqgTXCf3yD3rnx-BSPQVMCClKWclEwZoywccYsH0eBqharVL9t8rk-fyyxbPjaXcJ4JtQ3c-Cbeb44u83Y_8CZI2qYA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1266765787</pqid></control><display><type>article</type><title>Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV</title><source>Cambridge University Press</source><creator>Fellows, Robert P. ; Byrd, Desiree A. ; Elliott, Kathryn ; Robinson-Papp, Jessica ; Mindt, Monica Rivera ; Morgello, Susan</creator><creatorcontrib>Fellows, Robert P. ; Byrd, Desiree A. ; Elliott, Kathryn ; Robinson-Papp, Jessica ; Mindt, Monica Rivera ; Morgello, Susan ; Manhattan HIV Brain Bank</creatorcontrib><description>While distal sensory polyneuropathy (DSP) is the most common neurological condition associated with HIV, causing nerve damage in upper and lower extremities, its impact on neuropsychological test performance is unclear. In this study, we analyzed baseline data for 278 HIV-infected participants with comprehensive neurological and neurocognitive evaluations to examine the contribution of DSP and anatomic distribution of neuropathic signs (upper extremity or lower extremity) on standardized domain scores. We found that participants with DSP performed significantly worse in multiple domains containing timed psychomotor tests (i.e., motor, information processing speed and executive functioning). With regard to executive functioning, differences were limited to a test with a motor component (Trail Making Test, Part B). The group with clinically detectable neuropathic signs in the upper extremities and the group with signs limited to the lower extremities both performed worse in the motor domain than the group without DSP. Participants with DSP demonstrated a unique pattern of impairment limited to neuropsychological domains with timed psychomotor tests. These results suggest that caution should be used in interpretation of neuropsychological tests in patients with DSP, as some abnormalities may be exacerbated by peripheral nervous system pathology. (JINS, 2012, 19, 1–10)</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617712000707</identifier><identifier>PMID: 22691455</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Analysis of Variance ; Asymptomatic ; Chi-Square Distribution ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Dementia ; Drug therapy ; Executive function ; Executive Function - physiology ; Female ; Hands ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Humans ; Infections ; Information processing ; Male ; Middle Aged ; Neurologic Examination ; Neuropsychological Tests ; Neuropsychology ; Peripheral neuropathy ; Polyneuropathies - complications ; Polyneuropathies - etiology ; Processing speed ; Psychiatric Status Rating Scales ; Psychomotor Performance - physiology ; Sensory perception ; Verbal learning ; Working groups</subject><ispartof>Journal of the International Neuropsychological Society, 2012-09, Vol.18 (5), p.898-907</ispartof><rights>Copyright © The International Neuropsychological Society 2012</rights><rights>Copyright © INS. Published by Cambridge University Press, 2012. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3</citedby><cites>FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617712000707/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,72960</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22691455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fellows, Robert P.</creatorcontrib><creatorcontrib>Byrd, Desiree A.</creatorcontrib><creatorcontrib>Elliott, Kathryn</creatorcontrib><creatorcontrib>Robinson-Papp, Jessica</creatorcontrib><creatorcontrib>Mindt, Monica Rivera</creatorcontrib><creatorcontrib>Morgello, Susan</creatorcontrib><creatorcontrib>Manhattan HIV Brain Bank</creatorcontrib><title>Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>While distal sensory polyneuropathy (DSP) is the most common neurological condition associated with HIV, causing nerve damage in upper and lower extremities, its impact on neuropsychological test performance is unclear. In this study, we analyzed baseline data for 278 HIV-infected participants with comprehensive neurological and neurocognitive evaluations to examine the contribution of DSP and anatomic distribution of neuropathic signs (upper extremity or lower extremity) on standardized domain scores. We found that participants with DSP performed significantly worse in multiple domains containing timed psychomotor tests (i.e., motor, information processing speed and executive functioning). With regard to executive functioning, differences were limited to a test with a motor component (Trail Making Test, Part B). The group with clinically detectable neuropathic signs in the upper extremities and the group with signs limited to the lower extremities both performed worse in the motor domain than the group without DSP. Participants with DSP demonstrated a unique pattern of impairment limited to neuropsychological domains with timed psychomotor tests. These results suggest that caution should be used in interpretation of neuropsychological tests in patients with DSP, as some abnormalities may be exacerbated by peripheral nervous system pathology. (JINS, 2012, 19, 1–10)</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Analysis of Variance</subject><subject>Asymptomatic</subject><subject>Chi-Square Distribution</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Dementia</subject><subject>Drug therapy</subject><subject>Executive function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Hands</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Information processing</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurologic Examination</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Peripheral neuropathy</subject><subject>Polyneuropathies - complications</subject><subject>Polyneuropathies - etiology</subject><subject>Processing speed</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychomotor Performance - physiology</subject><subject>Sensory perception</subject><subject>Verbal learning</subject><subject>Working groups</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAUhS3UCijtA7CpInXDJtTXTuxkUwlB-ZFQQYJ2a3mcmxnTxB7spChvXw8zIGjFypbPd47v0SVkH-ghUJBfb4CXpQApgVFKJZVbZBcKUedSCHiX7knOV_oO-RDjHaXAgdJtssOYqKEoy13y-8TGQXfZDbrow5Rd-25yOAa_1MNiymzMjmL0xuoBm-zBDovsx6MaJ7PwnZ9bk8y3GIfsGkPrQ6-dwUz33s1XL9G7uLadX_z6SN63uov4aXPukZ-n32-Pz_PLq7OL46PL3BQShhx4YQrE1jRQUJb6MK5nYpbmbVnDhZZQt2go1iut0qyh2BTSCE2R0Zo3fI98W-cux1mPjUE3BN2pZbC9DpPy2qrXirMLNfd_FC8liApSwMEmIPj7MZVTvY0Gu0479GNUQLmsqgTXCf3yD3rnx-BSPQVMCClKWclEwZoywccYsH0eBqharVL9t8rk-fyyxbPjaXcJ4JtQ3c-Cbeb44u83Y_8CZI2qYA</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Fellows, Robert P.</creator><creator>Byrd, Desiree A.</creator><creator>Elliott, Kathryn</creator><creator>Robinson-Papp, Jessica</creator><creator>Mindt, Monica Rivera</creator><creator>Morgello, Susan</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV</title><author>Fellows, Robert P. ; Byrd, Desiree A. ; Elliott, Kathryn ; Robinson-Papp, Jessica ; Mindt, Monica Rivera ; Morgello, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Analysis of Variance</topic><topic>Asymptomatic</topic><topic>Chi-Square Distribution</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Dementia</topic><topic>Drug therapy</topic><topic>Executive function</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Hands</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Information processing</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurologic Examination</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Peripheral neuropathy</topic><topic>Polyneuropathies - complications</topic><topic>Polyneuropathies - etiology</topic><topic>Processing speed</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychomotor Performance - physiology</topic><topic>Sensory perception</topic><topic>Verbal learning</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fellows, Robert P.</creatorcontrib><creatorcontrib>Byrd, Desiree A.</creatorcontrib><creatorcontrib>Elliott, Kathryn</creatorcontrib><creatorcontrib>Robinson-Papp, Jessica</creatorcontrib><creatorcontrib>Mindt, Monica Rivera</creatorcontrib><creatorcontrib>Morgello, Susan</creatorcontrib><creatorcontrib>Manhattan HIV Brain Bank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fellows, Robert P.</au><au>Byrd, Desiree A.</au><au>Elliott, Kathryn</au><au>Robinson-Papp, Jessica</au><au>Mindt, Monica Rivera</au><au>Morgello, Susan</au><aucorp>Manhattan HIV Brain Bank</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>18</volume><issue>5</issue><spage>898</spage><epage>907</epage><pages>898-907</pages><issn>1355-6177</issn><eissn>1469-7661</eissn><abstract>While distal sensory polyneuropathy (DSP) is the most common neurological condition associated with HIV, causing nerve damage in upper and lower extremities, its impact on neuropsychological test performance is unclear. In this study, we analyzed baseline data for 278 HIV-infected participants with comprehensive neurological and neurocognitive evaluations to examine the contribution of DSP and anatomic distribution of neuropathic signs (upper extremity or lower extremity) on standardized domain scores. We found that participants with DSP performed significantly worse in multiple domains containing timed psychomotor tests (i.e., motor, information processing speed and executive functioning). With regard to executive functioning, differences were limited to a test with a motor component (Trail Making Test, Part B). The group with clinically detectable neuropathic signs in the upper extremities and the group with signs limited to the lower extremities both performed worse in the motor domain than the group without DSP. Participants with DSP demonstrated a unique pattern of impairment limited to neuropsychological domains with timed psychomotor tests. These results suggest that caution should be used in interpretation of neuropsychological tests in patients with DSP, as some abnormalities may be exacerbated by peripheral nervous system pathology. (JINS, 2012, 19, 1–10)</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>22691455</pmid><doi>10.1017/S1355617712000707</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1355-6177 |
ispartof | Journal of the International Neuropsychological Society, 2012-09, Vol.18 (5), p.898-907 |
issn | 1355-6177 1469-7661 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3571681 |
source | Cambridge University Press |
subjects | Acquired immune deficiency syndrome Adult AIDS Analysis of Variance Asymptomatic Chi-Square Distribution Cognition Disorders - diagnosis Cognition Disorders - etiology Dementia Drug therapy Executive function Executive Function - physiology Female Hands HIV HIV Infections - complications Human immunodeficiency virus Humans Infections Information processing Male Middle Aged Neurologic Examination Neuropsychological Tests Neuropsychology Peripheral neuropathy Polyneuropathies - complications Polyneuropathies - etiology Processing speed Psychiatric Status Rating Scales Psychomotor Performance - physiology Sensory perception Verbal learning Working groups |
title | Distal Sensory Polyneuropathy is Associated with Neuropsychological Test Performance among Persons with HIV |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A10%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distal%20Sensory%20Polyneuropathy%20is%20Associated%20with%20Neuropsychological%20Test%20Performance%20among%20Persons%20with%20HIV&rft.jtitle=Journal%20of%20the%20International%20Neuropsychological%20Society&rft.au=Fellows,%20Robert%20P.&rft.aucorp=Manhattan%20HIV%20Brain%20Bank&rft.date=2012-09-01&rft.volume=18&rft.issue=5&rft.spage=898&rft.epage=907&rft.pages=898-907&rft.issn=1355-6177&rft.eissn=1469-7661&rft_id=info:doi/10.1017/S1355617712000707&rft_dat=%3Cproquest_pubme%3E2858614091%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c471t-134c4eefcd140214623ab6b145f2d36a719fec0e921468a2d0ed47c6a0e2093d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1266765787&rft_id=info:pmid/22691455&rft_cupid=10_1017_S1355617712000707&rfr_iscdi=true |