In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) belong to a group of bacteria known as attaching and effacing (A/E) pathogens that cause disease by adhering to the lumenal surfaces of their host's intestinal epithelium. EPEC and EHEC are major causes of infectious...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2013-03, Vol.3 (3), p.a009977-a009977
Main Authors: Law, Robyn J, Gur-Arie, Lihi, Rosenshine, Ilan, Finlay, B Brett
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cells, Cultured
Disease Models, Animal
Enteropathogenic Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Gastroenteritis - microbiology
Humans
Models, Biological
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Summary:Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) belong to a group of bacteria known as attaching and effacing (A/E) pathogens that cause disease by adhering to the lumenal surfaces of their host's intestinal epithelium. EPEC and EHEC are major causes of infectious diarrhea that result in significant childhood morbidity and mortality worldwide. Recent advances in in vitro and in vivo modeling of these pathogens have contributed to our knowledge of how EPEC and EHEC attach to host cells and subvert host-cell signaling pathways to promote infection and cause disease. A more detailed understanding of how these pathogenic microbes infect their hosts and how the host responds to infection could ultimately lead to new therapeutic strategies to help control these significant enteric pathogens.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a009977