Association between locomotor response to novelty and light reinforcement: Sensory reinforcement as a rodent model of sensation seeking

• Published in: Behavioural brain research 2012-05, Vol.230 (2), p.380-388
• Main Authors: Gancarz, Amy M., Robble, Mykel A., Kausch, Michael A., Lloyd, David R., Richards, Jerry B.
• Format: Article
• Language: English
• Subjects: Animals; Conditioning, Operant; Drug abuse; Exploratory Behavior; Individual differences; Light; Male; Models, Animal; Motor Activity; Operant conditioning; Photic Stimulation; Rat; Rats; Reinforcement (Psychology); Self-administration; Visual stimuli
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2012.02.028

► Total responses, but not preference for a response contingent light is correlated with locomotor response to novelty. ► HR rats responded more to produce a response contingent light than LR rats. ► HR rats habituated slower to a novel environment and a response contingent light compared to LR rats. The human personality trait of sensation seeking (SS) indicates an attraction to novel sensations and experiences, and is associated with greater likelihood of drug abuse. In rodents, locomotor activity in a novel environment (Loco) has been found to predict drug self-administration (SA), and has been hypothesized to be a translational model of human SS. Previously, we reported (Gancarz et al., 2011 [12]) that high responder (HR) animals responded more than low responder (LR) animals to produce a response contingent light onset. The primary goal of this paper was a detailed analysis of the association between Loco and light contingent responding in a large sample of rats (n=93). Male rats were pre-exposed to dark operant test chambers for ten 30min sessions and baseline levels of responding (snout poking) were determined. The pre-exposure phase was followed by 6 sessions during which active responding produced a visual sensory reinforcer (VSR; 5s light onset) according to a variable interval 1min schedule of reinforcement. After completion of the VSR phase, Loco was tested. The activating effects (total responding) of light were associated with Loco, but the response guiding effects (proportion of active responding) of the light were not. In addition, HR rats habituated more slowly in both the VSR and Loco tests than LR rats. These data indicate that VSR measures aspects of the rodent's response to novel sensations and experiences that are not detected by Loco. These data provide some evidence for the use of light reinforcement as an animal model of SS.