Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

• Published in: Acta biomaterialia 2012-09, Vol.8 (9), p.3270-3282
• Main Authors: Gong, Shi-qiang, Niu, Li-na, Kemp, Lisa K., Yiu, Cynthia K.Y., Ryou, Heonjune, Qi, Yi-pin, Blizzard, John D., Nikonov, Sergey, Brackett, Martha G., Messer, Regina L.W., Wu, Christine D., Mao, Jing, Bryan Brister, L., Rueggeberg, Frederick A., Arola, Dwayne D., Pashley, David H., Tay, Franklin R.
• Format: Article
• Language: English
• Subjects: Actinomyces - drug effects; Actinomyces naeslundii; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; anti-infective properties; Antimicrobial; biofilm; Candida albicans; Candida albicans - drug effects; condensation; Flow Cytometry; health services; Magnetic Resonance Spectroscopy; mechanical properties; Methacrylates - chemistry; Methacrylates - pharmacology; Mice; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Organic modified silicate; polymerization; polymers; propane; Quaternary ammonium; Quaternary Ammonium Compounds - chemistry; Self-repair; shrinkage; Silanes - chemistry; Sol–gel technique; Spectroscopy, Fourier Transform Infrared; Streptococcus mutans; Streptococcus mutans - drug effects; Thermogravimetry
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2012.05.031

The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol–gel chemical route; these compounds possess flexible Si–O–Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.