Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cell...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-9
Main Authors: Xu, Fanxing, Graves, Dana T., Zhang, Chenying
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Differentiation
Cell Proliferation
Diabetes Mellitus - metabolism
Diabetes Mellitus - pathology
Fibroblasts - metabolism
Fibroblasts - pathology
Gene Expression Regulation
Humans
Keratinocytes - metabolism
Keratinocytes - pathology
Macrophages - metabolism
Macrophages - pathology
Mesenchymal Stromal Cells - metabolism
Mesenchymal Stromal Cells - pathology
Review
Tumor Necrosis Factor-alpha - biosynthesis
Wound Healing
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Summary:Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/754802