Extremely Low-Frequency Magnetic Field Enhances the Therapeutic Efficacy of Low-Dose Cisplatin in the Treatment of Ehrlich Carcinoma

The present study examines the therapeutic efficacy of the administration of low-dose cisplatin (cis) followed by exposure to extremely low-frequency magnetic field (ELF-MF), with an average intensity of 10 mT, on Ehrlich carcinoma in vivo. The cytotoxic and genotoxic actions of this combination wer...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-7
Main Authors: El-Bialy, Nihal S., Rageh, Monira M.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Animals
Antineoplastic Agents - pharmacology
Carcinoma
Carcinoma, Ehrlich Tumor - drug therapy
Carcinoma, Ehrlich Tumor - metabolism
Carcinoma, Ehrlich Tumor - pathology
Cisplatin
Cisplatin - pharmacology
Comparative analysis
Dosage and administration
Dose-Response Relationship, Drug
Drug therapy
Female
Health aspects
Magnetic Field Therapy - methods
Magnetic fields
Mice
Mice, Inbred BALB C
Time Factors
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Summary:The present study examines the therapeutic efficacy of the administration of low-dose cisplatin (cis) followed by exposure to extremely low-frequency magnetic field (ELF-MF), with an average intensity of 10 mT, on Ehrlich carcinoma in vivo. The cytotoxic and genotoxic actions of this combination were studied using comet assay, mitotic index (MI), and the induction of micronucleus (MN). Moreover, the inhibition of tumor growth was also measured. Treatment with cisplatin and ELF-MF (group A) increased the number of damaged cells by 54% compared with 41% for mice treated with cisplatin alone (group B), 20% for mice treated by exposure to ELF-MF (group C), and 9% for the control group (group D). Also the mitotic index decreased significantly for all treated groups (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/189352