Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 pat...

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Bibliographic Details
Published in:Cell stress & chaperones 2013-03, Vol.18 (2), p.235-241
Main Authors: Gruden, Gabriella, Carucci, Patrizia, Lolli, Valentina, Cosso, Loretta, Dellavalle, Erika, Rolle, Emanuela, Cantamessa, Alessandro, Pinach, Silvia, Abate, Maria Lorena, Campra, Donata, Brunello, Franco, Bruno, Graziella, Rizzetto, Mario, Perin, Paolo Cavallo
Format: Article
Language:English
Subjects:
Aged
alpha-Fetoproteins - analysis
Biochemistry
Biological markers
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Cell Biology
Female
Heat shock proteins
Hepatitis
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - pathology
Hepatocellular carcinoma
HSP27 Heat-Shock Proteins - blood
Humans
Immunology
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases - blood
Liver Diseases - pathology
Liver Neoplasms - blood
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasia
Neoplasm Staging
Neurosciences
Nodules
Odds Ratio
Original Paper
Peptide Fragments - blood
Prognosis
Prothrombin
Risk Factors
ROC Curve
Severity of Illness Index
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Summary:Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p
ISSN:1355-8145
1466-1268
DOI:10.1007/s12192-012-0377-8