Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 pat...

Full description

Saved in:
Bibliographic Details
Published in:Cell stress & chaperones 2013-03, Vol.18 (2), p.235-241
Main Authors: Gruden, Gabriella, Carucci, Patrizia, Lolli, Valentina, Cosso, Loretta, Dellavalle, Erika, Rolle, Emanuela, Cantamessa, Alessandro, Pinach, Silvia, Abate, Maria Lorena, Campra, Donata, Brunello, Franco, Bruno, Graziella, Rizzetto, Mario, Perin, Paolo Cavallo
Format: Article
Language:English
Subjects:
Aged
alpha-Fetoproteins - analysis
Biochemistry
Biological markers
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Cell Biology
Female
Heat shock proteins
Hepatitis
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - pathology
Hepatocellular carcinoma
HSP27 Heat-Shock Proteins - blood
Humans
Immunology
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases - blood
Liver Diseases - pathology
Liver Neoplasms - blood
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasia
Neoplasm Staging
Neurosciences
Nodules
Odds Ratio
Original Paper
Peptide Fragments - blood
Prognosis
Prothrombin
Risk Factors
ROC Curve
Severity of Illness Index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3
cites cdi_FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3
container_end_page 241
container_issue 2
container_start_page 235
container_title Cell stress & chaperones
container_volume 18
creator Gruden, Gabriella
Carucci, Patrizia
Lolli, Valentina
Cosso, Loretta
Dellavalle, Erika
Rolle, Emanuela
Cantamessa, Alessandro
Pinach, Silvia
Abate, Maria Lorena
Campra, Donata
Brunello, Franco
Bruno, Graziella
Rizzetto, Mario
Perin, Paolo Cavallo
description Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p
doi_str_mv 10.1007/s12192-012-0377-8
format article
fullrecord <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3581631</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>23610176</jstor_id><sourcerecordid>23610176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3</originalsourceid><addsrcrecordid>eNp9kUtP3DAUha0KVCjtD2DRKhKbbgK-dvzIphJCfUkjsaBdW459h8mQxFM7GdR_Xw-haGDBwrKv_Z3je3UIOQV6DpSqiwQMalZSyIsrVeo35BgqKUtgUh_kMxei1FCJI_IupTXNGqXgLTlinCouBT8mixuMU1-s0I5FWgV3V2xiGLEdCqaKDrfYpSIXGzu2OIypuG_HVaZzHRx23dTZWDgbXTuE3r4nh0vbJfzwuJ-Q39--_rr6US6uv_-8ulyUrqrZWALQBpaVFw54wzyTta8bgfmCWSYqZxuKspZeS6-kR1BUu2qJFK2SWnjPT8iX2XczNT16lzuLtjOb2PY2_jXBtub5y9CuzG3YGi40SA7Z4POjQQx_Jkyj6du0m8cOGKZkgAPTXHPFMnr2Al2HKQ55vAeqolSyOlMwUy6GlCIun5oBanZZmTkrk7Myu6yMzppP-1M8Kf6HkwE2Ayk_DbcY975-xfXjLFqnMcQ9UwkUlOT_AIGgqSA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1312400629</pqid></control><display><type>article</type><title>Serum heat shock protein 27 levels in patients with hepatocellular carcinoma</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Springer Nature</source><source>Elsevier ScienceDirect Journals</source><source>PubMed Central</source><creator>Gruden, Gabriella ; Carucci, Patrizia ; Lolli, Valentina ; Cosso, Loretta ; Dellavalle, Erika ; Rolle, Emanuela ; Cantamessa, Alessandro ; Pinach, Silvia ; Abate, Maria Lorena ; Campra, Donata ; Brunello, Franco ; Bruno, Graziella ; Rizzetto, Mario ; Perin, Paolo Cavallo</creator><creatorcontrib>Gruden, Gabriella ; Carucci, Patrizia ; Lolli, Valentina ; Cosso, Loretta ; Dellavalle, Erika ; Rolle, Emanuela ; Cantamessa, Alessandro ; Pinach, Silvia ; Abate, Maria Lorena ; Campra, Donata ; Brunello, Franco ; Bruno, Graziella ; Rizzetto, Mario ; Perin, Paolo Cavallo</creatorcontrib><description>Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p&lt;0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1007/s12192-012-0377-8</identifier><identifier>PMID: 23073653</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Aged ; alpha-Fetoproteins - analysis ; Biochemistry ; Biological markers ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - pathology ; Cell Biology ; Female ; Heat shock proteins ; Hepatitis ; Hepatitis C - blood ; Hepatitis C - complications ; Hepatitis C - pathology ; Hepatocellular carcinoma ; HSP27 Heat-Shock Proteins - blood ; Humans ; Immunology ; Liver ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver Cirrhosis - pathology ; Liver diseases ; Liver Diseases - blood ; Liver Diseases - pathology ; Liver Neoplasms - blood ; Liver Neoplasms - etiology ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Neoplasia ; Neoplasm Staging ; Neurosciences ; Nodules ; Odds Ratio ; Original Paper ; Peptide Fragments - blood ; Prognosis ; Prothrombin ; Risk Factors ; ROC Curve ; Severity of Illness Index</subject><ispartof>Cell stress &amp; chaperones, 2013-03, Vol.18 (2), p.235-241</ispartof><rights>Cell Stress Society International 2013</rights><rights>Cell Stress Society International 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3</citedby><cites>FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23610176$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23610176$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791,58236,58469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23073653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruden, Gabriella</creatorcontrib><creatorcontrib>Carucci, Patrizia</creatorcontrib><creatorcontrib>Lolli, Valentina</creatorcontrib><creatorcontrib>Cosso, Loretta</creatorcontrib><creatorcontrib>Dellavalle, Erika</creatorcontrib><creatorcontrib>Rolle, Emanuela</creatorcontrib><creatorcontrib>Cantamessa, Alessandro</creatorcontrib><creatorcontrib>Pinach, Silvia</creatorcontrib><creatorcontrib>Abate, Maria Lorena</creatorcontrib><creatorcontrib>Campra, Donata</creatorcontrib><creatorcontrib>Brunello, Franco</creatorcontrib><creatorcontrib>Bruno, Graziella</creatorcontrib><creatorcontrib>Rizzetto, Mario</creatorcontrib><creatorcontrib>Perin, Paolo Cavallo</creatorcontrib><title>Serum heat shock protein 27 levels in patients with hepatocellular carcinoma</title><title>Cell stress &amp; chaperones</title><addtitle>Cell Stress and Chaperones</addtitle><addtitle>Cell Stress Chaperones</addtitle><description>Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p&lt;0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.</description><subject>Aged</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biochemistry</subject><subject>Biological markers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Heat shock proteins</subject><subject>Hepatitis</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - pathology</subject><subject>Hepatocellular carcinoma</subject><subject>HSP27 Heat-Shock Proteins - blood</subject><subject>Humans</subject><subject>Immunology</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - pathology</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasia</subject><subject>Neoplasm Staging</subject><subject>Neurosciences</subject><subject>Nodules</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Peptide Fragments - blood</subject><subject>Prognosis</subject><subject>Prothrombin</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><issn>1355-8145</issn><issn>1466-1268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kUtP3DAUha0KVCjtD2DRKhKbbgK-dvzIphJCfUkjsaBdW459h8mQxFM7GdR_Xw-haGDBwrKv_Z3je3UIOQV6DpSqiwQMalZSyIsrVeo35BgqKUtgUh_kMxei1FCJI_IupTXNGqXgLTlinCouBT8mixuMU1-s0I5FWgV3V2xiGLEdCqaKDrfYpSIXGzu2OIypuG_HVaZzHRx23dTZWDgbXTuE3r4nh0vbJfzwuJ-Q39--_rr6US6uv_-8ulyUrqrZWALQBpaVFw54wzyTta8bgfmCWSYqZxuKspZeS6-kR1BUu2qJFK2SWnjPT8iX2XczNT16lzuLtjOb2PY2_jXBtub5y9CuzG3YGi40SA7Z4POjQQx_Jkyj6du0m8cOGKZkgAPTXHPFMnr2Al2HKQ55vAeqolSyOlMwUy6GlCIun5oBanZZmTkrk7Myu6yMzppP-1M8Kf6HkwE2Ayk_DbcY975-xfXjLFqnMcQ9UwkUlOT_AIGgqSA</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Gruden, Gabriella</creator><creator>Carucci, Patrizia</creator><creator>Lolli, Valentina</creator><creator>Cosso, Loretta</creator><creator>Dellavalle, Erika</creator><creator>Rolle, Emanuela</creator><creator>Cantamessa, Alessandro</creator><creator>Pinach, Silvia</creator><creator>Abate, Maria Lorena</creator><creator>Campra, Donata</creator><creator>Brunello, Franco</creator><creator>Bruno, Graziella</creator><creator>Rizzetto, Mario</creator><creator>Perin, Paolo Cavallo</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130301</creationdate><title>Serum heat shock protein 27 levels in patients with hepatocellular carcinoma</title><author>Gruden, Gabriella ; Carucci, Patrizia ; Lolli, Valentina ; Cosso, Loretta ; Dellavalle, Erika ; Rolle, Emanuela ; Cantamessa, Alessandro ; Pinach, Silvia ; Abate, Maria Lorena ; Campra, Donata ; Brunello, Franco ; Bruno, Graziella ; Rizzetto, Mario ; Perin, Paolo Cavallo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biochemistry</topic><topic>Biological markers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Heat shock proteins</topic><topic>Hepatitis</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - pathology</topic><topic>Hepatocellular carcinoma</topic><topic>HSP27 Heat-Shock Proteins - blood</topic><topic>Humans</topic><topic>Immunology</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver diseases</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - pathology</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasia</topic><topic>Neoplasm Staging</topic><topic>Neurosciences</topic><topic>Nodules</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Peptide Fragments - blood</topic><topic>Prognosis</topic><topic>Prothrombin</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruden, Gabriella</creatorcontrib><creatorcontrib>Carucci, Patrizia</creatorcontrib><creatorcontrib>Lolli, Valentina</creatorcontrib><creatorcontrib>Cosso, Loretta</creatorcontrib><creatorcontrib>Dellavalle, Erika</creatorcontrib><creatorcontrib>Rolle, Emanuela</creatorcontrib><creatorcontrib>Cantamessa, Alessandro</creatorcontrib><creatorcontrib>Pinach, Silvia</creatorcontrib><creatorcontrib>Abate, Maria Lorena</creatorcontrib><creatorcontrib>Campra, Donata</creatorcontrib><creatorcontrib>Brunello, Franco</creatorcontrib><creatorcontrib>Bruno, Graziella</creatorcontrib><creatorcontrib>Rizzetto, Mario</creatorcontrib><creatorcontrib>Perin, Paolo Cavallo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell stress &amp; chaperones</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruden, Gabriella</au><au>Carucci, Patrizia</au><au>Lolli, Valentina</au><au>Cosso, Loretta</au><au>Dellavalle, Erika</au><au>Rolle, Emanuela</au><au>Cantamessa, Alessandro</au><au>Pinach, Silvia</au><au>Abate, Maria Lorena</au><au>Campra, Donata</au><au>Brunello, Franco</au><au>Bruno, Graziella</au><au>Rizzetto, Mario</au><au>Perin, Paolo Cavallo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum heat shock protein 27 levels in patients with hepatocellular carcinoma</atitle><jtitle>Cell stress &amp; chaperones</jtitle><stitle>Cell Stress and Chaperones</stitle><addtitle>Cell Stress Chaperones</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>18</volume><issue>2</issue><spage>235</spage><epage>241</epage><pages>235-241</pages><issn>1355-8145</issn><eissn>1466-1268</eissn><abstract>Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p&lt;0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>23073653</pmid><doi>10.1007/s12192-012-0377-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1355-8145
ispartof Cell stress & chaperones, 2013-03, Vol.18 (2), p.235-241
issn 1355-8145
1466-1268
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3581631
source JSTOR Archival Journals and Primary Sources Collection; Springer Nature; Elsevier ScienceDirect Journals; PubMed Central
subjects Aged
alpha-Fetoproteins - analysis
Biochemistry
Biological markers
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Cell Biology
Female
Heat shock proteins
Hepatitis
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - pathology
Hepatocellular carcinoma
HSP27 Heat-Shock Proteins - blood
Humans
Immunology
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases - blood
Liver Diseases - pathology
Liver Neoplasms - blood
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasia
Neoplasm Staging
Neurosciences
Nodules
Odds Ratio
Original Paper
Peptide Fragments - blood
Prognosis
Prothrombin
Risk Factors
ROC Curve
Severity of Illness Index
title Serum heat shock protein 27 levels in patients with hepatocellular carcinoma
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T19%3A09%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20heat%20shock%20protein%2027%20levels%20in%20patients%20with%20hepatocellular%20carcinoma&rft.jtitle=Cell%20stress%20&%20chaperones&rft.au=Gruden,%20Gabriella&rft.date=2013-03-01&rft.volume=18&rft.issue=2&rft.spage=235&rft.epage=241&rft.pages=235-241&rft.issn=1355-8145&rft.eissn=1466-1268&rft_id=info:doi/10.1007/s12192-012-0377-8&rft_dat=%3Cjstor_pubme%3E23610176%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c492t-110b1f4d5c13b2d269d9b5e4d52a254cab0e696d86d76de1708c4fe0ea7685dd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1312400629&rft_id=info:pmid/23073653&rft_jstor_id=23610176&rfr_iscdi=true