Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8 + T cells

We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8 T cells in the genital mucosa of mice, without affecti...

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Bibliographic Details
Published in:Oncoimmunology 2013-01, Vol.2 (1), p.e22944-e22944
Main Authors: Decrausaz, Loane, Pythoud, Christelle, Domingos-Pereira, Sonia, Derré, Laurent, Jichlinski, Patrice, Nardelli-Haefliger, Denise
Format: Article
Language:English
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Brief Report
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Summary:We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8 T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of live attenuated serovar Typhimurium similarly, though more efficiently (~15- fold), increases both E7-specific and total CD8 T cells in the genital mucosa. Cancer immunotherapeutic strategies combining vaccination with local immunostimulation with live bacteria deserve further investigations.
ISSN:2162-4011
2162-402X
DOI:10.4161/onci.22944