Neurophysiological pharmacodynamic measures of groups and individuals extended from simple cognitive tasks to more “lifelike” activities

Highlights ► In an exploratory–confirmatory paradigm, an equation combining beta and theta EEG power tracked the effect of an exemplar psychoactive substance (alcohol) for 4 h. ► The equation, derived on repetitive cognitive task EEG data in the Exploratory Study, worked well when applied in the Con...

Full description

Saved in:
Bibliographic Details
Published in:Clinical neurophysiology 2013-05, Vol.124 (5), p.870-880
Main Authors: Gevins, Alan, Chan, Cynthia S, Jiang, An, Sam-Vargas, Lita
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alcohol Drinking
Automobile driving simulator
Brain - drug effects
Brain - physiology
Cognition
Cognition - drug effects
Cognition - physiology
EEG
Electroencephalography - methods
Ethanol - pharmacology
Female
Humans
Integrated brain function
Lifelike task
Male
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Middle Aged
Nervous System Physiological Phenomena - drug effects
Neurology
Pattern recognition
Pharmacodynamics
Psychoactive drugs
Psychomotor Performance - drug effects
Reaction Time
Working memory
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► In an exploratory–confirmatory paradigm, an equation combining beta and theta EEG power tracked the effect of an exemplar psychoactive substance (alcohol) for 4 h. ► The equation, derived on repetitive cognitive task EEG data in the Exploratory Study, worked well when applied in the Confirmatory Study to track alcohol’s EEG effects on a working memory task and on a simulated automobile driving task. ► This suggests that EEG biomarkers may prove useful for assessing, both in groups and individuals, neurophysiological effects of psychoactive substances on both basic cognitive processes and integrated brain functioning in relation to other biomarkers and behavior.
ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2012.10.013