Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum

Highlights ► The GTPase Rhes is required for lithium to acutely phosphorylate Akt and GSK3. ► D1/D2 agonist apomorphine increases Akt and GSK3 phosphorylation in rhes−/− mice. ► Rhes interacts with beta-arrestins. ► A multi-protein complex in the striatum is altered in the absence of Rhes protein....

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Bibliographic Details
Published in:Neuroscience 2013-04, Vol.236, p.21-30
Main Authors: Harrison, L.M, Muller, S.H, Spano, D
Format: Article
Language:English
Subjects:
Animals
Blotting, Western
Corpus Striatum - metabolism
dopamine
G protein
Glycogen Synthase Kinase 3 - metabolism
Glycogen Synthase Kinase 3 beta
GTP-Binding Proteins - metabolism
Immunoprecipitation
lithium
Lithium Chloride - pharmacology
Mice
Mice, Knockout
Neurology
Phosphorylation
Proto-Oncogene Proteins c-akt - metabolism
Rasd2
Signal Transduction - physiology
striatum
β-arrestins
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Summary:Highlights ► The GTPase Rhes is required for lithium to acutely phosphorylate Akt and GSK3. ► D1/D2 agonist apomorphine increases Akt and GSK3 phosphorylation in rhes−/− mice. ► Rhes interacts with beta-arrestins. ► A multi-protein complex in the striatum is altered in the absence of Rhes protein.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.12.062