No Association between Ovarian Cancer Susceptibility Variants and Breast Cancer Risk among Chinese Women

As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer. Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Ca...

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Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2013-03, Vol.22 (3), p.467-469
Main Authors: XIANGYU MA, QIUYIN CAI, DELAHANTY, Ryan J, SHU, Xiao-Ou, BEN ZHANG, WEI LU, GAO, Yu-Tang, WEI ZHENG, JIRONG LONG, BEEGHLY-FADIEL, Alicia
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - genetics
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Case-Control Studies
China - epidemiology
Disease Susceptibility
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Meta-Analysis as Topic
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Ovarian Neoplasms - epidemiology
Ovarian Neoplasms - etiology
Polymorphism, Single Nucleotide - genetics
Prognosis
Risk Factors
Tumors
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Summary:As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer. Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls. No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05). Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women. These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-12-1365