Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides

Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies...

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Bibliographic Details
Published in:Scientific reports 2013-03, Vol.3 (1), p.1456, Article 1456
Main Authors: Zhu, Fang, Gujar, Hemant, Gordon, Jennifer R., Haynes, Kenneth F., Potter, Michael F., Palli, Subba R.
Format: Article
Language:English
Subjects:
631/337
631/45
631/601/1466
631/61/212
Adaptation
Animals
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Bedbugs - drug effects
Bedbugs - genetics
Bedbugs - metabolism
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Evolution
Female
Gene Expression Profiling
Genome
Humanities and Social Sciences
Insect Proteins - antagonists & inhibitors
Insect Proteins - genetics
Insect Proteins - metabolism
Insecticide Resistance - genetics
Insecticides
Insecticides - toxicity
Insects
multidisciplinary
Mutation
Pesticide resistance
Physical characteristics
Pyrethrins - toxicity
Pyrethroids
RNA Interference
Science
Toxins
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Summary:Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance ( kdr ) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01456