Effect of pomegranate juice on paraoxonase enzyme activity in patients with type 2 diabetes

Objective(s) Paraoxonase-1 (PON1), an HDL-associated enzyme, prevents lipoprotein oxidation. PON1 enzymatic activity has been shown to decrease in patients with diabetes. Paraoxonase activity. HDL capacity to bind with PON1 is possible under specific experimental conditions, such as oxidation, addit...

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Published in:Journal of diabetes and metabolic disorders 2012-08, Vol.11 (1), p.11-11, Article 11
Main Authors: Parsaeyan, Nayereh, Mozaffari–Khosravi, Hassan, Mozayan, Mohammad Reza
Format: Article
Language:English
Subjects:
Antioxidants
Blood sugar
Care and treatment
Diabetes
Diabetics
Endocrinology
Enzymes
Fruit juices
Health aspects
Low density lipoproteins
Medicine
Medicine & Public Health
Metabolic Diseases
Physiological aspects
Polyphenols
Pomegranate
Research Article
Triglycerides
Type 2 diabetes
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Summary:Objective(s) Paraoxonase-1 (PON1), an HDL-associated enzyme, prevents lipoprotein oxidation. PON1 enzymatic activity has been shown to decrease in patients with diabetes. Paraoxonase activity. HDL capacity to bind with PON1 is possible under specific experimental conditions, such as oxidation, addition of polyphenols, or in diabetic patients with polyphenols doses. The aim of this study was the effect of pomegranate juice (PJ) on paraoxonase and arylesterase activity of PON1. Materials and methods Fifty patients with type 2 diabetes mellitus consumed 200 ml of PJ daily for a period of 6 weeks. Blood was collected from the patients before and after PJ consumption after 12 h of fasting. Blood sugar, total cholesterol, triglyceride, LDL- C and HDL-C were measured by colorimetric kit method. The malondialdehyde concentration (μmol/L) was determined by thiobarbituric acid (TBA) assay. Paraoxonase and arylesterase activity of PON1 enzyme were measured using paraoxone and phenylacetate as the substrates. Results The concentration of fasting blood sugar, total cholesterol, LDL-C and malondialdehyde significantly (p 
ISSN:2251-6581
2251-6581
DOI:10.1186/2251-6581-11-11