Socio-economic, clinical and biological risk factors for mother - to - child transmission of HIV-1 in Muhima health centre (Rwanda): a prospective cohort study

Three decades since the first HIV-1 infected patients in Rwanda were identified in 1983; the Acquired Immunodeficiency Syndrome epidemic has had a devastating history and is still a major public health challenge in the country. This study was aimed at assessing socioeconomic, clinical and biological...

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Published in:Archives of public health = Archives belges de santé publique 2013-02, Vol.71 (1), p.4-4, Article 4
Main Authors: Bucagu, Maurice, Bizimana, Jean de Dieu, Muganda, John, Humblet, Claire Perrine
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Breastfeeding & lactation
Childbirth & labor
Children & youth
Cohort analysis
Disease transmission
Epidemics
GDP
Gross Domestic Product
Hemoglobin
HIV
HIV (Viruses)
HIV testing
Hospitals
Human immunodeficiency virus
Infections
Laboratories
Medical records
Medical research
Medicine, Experimental
Mothers
Population
Pregnancy
Pregnant women
Public health
Questionnaires
Risk factors
Rwanda
Womens health
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Summary:Three decades since the first HIV-1 infected patients in Rwanda were identified in 1983; the Acquired Immunodeficiency Syndrome epidemic has had a devastating history and is still a major public health challenge in the country. This study was aimed at assessing socioeconomic, clinical and biological risk factors for mother - to - child transmission of HIV- in Muhima health centre (Kigali/Rwanda). The prospective cohort study was conducted at Muhima Health centre (Kigali/Rwanda).During the study period (May 2007 - April 2010), of 8,669 pregnant women who attended antenatal visits and screened for HIV-1, 736 tested HIV-1 positive and among them 700 were eligible study participants. Hemoglobin, CD4 count and viral load tests were performed for participant mothers and HIV-1 testing using DNA PCR technique for infants.Follow up data for eligible mother-infant pairs were obtained from women themselves and log books in Muhima health centre and maternity, using a structured questionnaire.Predictors of mother-to-child transmission of HIV-1 were assessed by multivariable logistic regression analysis. Among the 679 exposed and followed-up infants, HIV-1 status was significantly associated with disclosure of HIV status to partner both at 6 weeks of age (non-disclosure of HIV status, adjusted odds ratio [AOR] 4.68, CI 1.39 to 15.77, p 
ISSN:0778-7367
2049-3258
2049-3258
DOI:10.1186/0778-7367-71-4