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Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986
The role of environmental factors in lumbar intervertebral disc degeneration (DD) in young adults is largely unknown. Therefore, we investigated whether body mass index (BMI), smoking, and physical activity are associated with lumbar DD among young adults. The Oulu Back Study (OBS) is a subpopulatio...
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Published in: | BMC musculoskeletal disorders 2013-03, Vol.14 (1), p.87-87, Article 87 |
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creator | Takatalo, Jani Karppinen, Jaro Taimela, Simo Niinimäki, Jaakko Laitinen, Jaana Blanco Sequeiros, Roberto Paananen, Markus Remes, Jouko Näyhä, Simo Tammelin, Tuija Korpelainen, Raija Tervonen, Osmo |
description | The role of environmental factors in lumbar intervertebral disc degeneration (DD) in young adults is largely unknown. Therefore, we investigated whether body mass index (BMI), smoking, and physical activity are associated with lumbar DD among young adults.
The Oulu Back Study (OBS) is a subpopulation of the 1986 Northern Finland Birth Cohort (NFBC 1986) and it originally included 2,969 children. The OBS subjects received a postal questionnaire, and those who responded (N = 1,987) were invited to the physical examination. The participants (N = 874) were invited to lumbar MRI study. A total of 558 young adults (325 females and 233 males) underwent MRI that used a 1.5-T scanner at the mean age of 21. Each lumbar intervertebral disc was graded as normal (0), mildly (1), moderately (2), or severely (3) degenerated. We calculated a sum score of the lumbar DD, and analyzed the associations between environmental risk factors (smoking, physical activity and weight-related factors assessed at 16 and 19 years) and DD using ordinal logistic regression, the results being expressed as cumulative odds ratios (COR). All analyses were stratified by gender.
Of the 558 subjects, 256 (46%) had no DD, 117 (21%) had sum score of one, 93 (17%) sum score of two, and 92 (17%) sum score of three or higher. In the multivariate ordinal logistic regression model, BMI at 16 years (highest vs. lowest quartile) was associated with DD sum score among males (COR 2.35; 95% CI 1.19-4.65) but not among females (COR 1.29; 95% CI 0.72-2.32). Smoking of at least four pack-years was associated with DD among males, but not among females (COR 2.41; 95% CI 0.99-5.86 and 1.59; 95% 0.67-3.76, respectively). Self-reported physical activity was not associated with DD.
High BMI at 16 years was associated with lumbar DD at 21 years among young males but not among females. High pack-years of smoking showed a comparable association in males, while physical activity had no association with DD in either gender. These results suggest that environmental factors are associated with DD among young males. |
doi_str_mv | 10.1186/1471-2474-14-87 |
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The Oulu Back Study (OBS) is a subpopulation of the 1986 Northern Finland Birth Cohort (NFBC 1986) and it originally included 2,969 children. The OBS subjects received a postal questionnaire, and those who responded (N = 1,987) were invited to the physical examination. The participants (N = 874) were invited to lumbar MRI study. A total of 558 young adults (325 females and 233 males) underwent MRI that used a 1.5-T scanner at the mean age of 21. Each lumbar intervertebral disc was graded as normal (0), mildly (1), moderately (2), or severely (3) degenerated. We calculated a sum score of the lumbar DD, and analyzed the associations between environmental risk factors (smoking, physical activity and weight-related factors assessed at 16 and 19 years) and DD using ordinal logistic regression, the results being expressed as cumulative odds ratios (COR). All analyses were stratified by gender.
Of the 558 subjects, 256 (46%) had no DD, 117 (21%) had sum score of one, 93 (17%) sum score of two, and 92 (17%) sum score of three or higher. In the multivariate ordinal logistic regression model, BMI at 16 years (highest vs. lowest quartile) was associated with DD sum score among males (COR 2.35; 95% CI 1.19-4.65) but not among females (COR 1.29; 95% CI 0.72-2.32). Smoking of at least four pack-years was associated with DD among males, but not among females (COR 2.41; 95% CI 0.99-5.86 and 1.59; 95% 0.67-3.76, respectively). Self-reported physical activity was not associated with DD.
High BMI at 16 years was associated with lumbar DD at 21 years among young males but not among females. High pack-years of smoking showed a comparable association in males, while physical activity had no association with DD in either gender. These results suggest that environmental factors are associated with DD among young males.</description><identifier>ISSN: 1471-2474</identifier><identifier>EISSN: 1471-2474</identifier><identifier>DOI: 10.1186/1471-2474-14-87</identifier><identifier>PMID: 23497297</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Body Mass Index ; Degeneration (Pathology) ; Exercise ; Female ; Finland - epidemiology ; Health aspects ; Humans ; Intervertebral Disc Degeneration - diagnosis ; Intervertebral Disc Degeneration - epidemiology ; Intervertebral disk ; Life Style ; Logistic Models ; Lumbar Vertebrae - pathology ; Magnetic Resonance Imaging ; Male ; Medical research ; Motor Activity ; NMR ; Nuclear magnetic resonance ; Odds Ratio ; Physical Examination ; Physical Fitness ; Physiological aspects ; Risk Factors ; Sex Factors ; Smoking - adverse effects ; Smoking - epidemiology ; Studies ; Surveys and Questionnaires ; Young Adult</subject><ispartof>BMC musculoskeletal disorders, 2013-03, Vol.14 (1), p.87-87, Article 87</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Takatalo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2013 Takatalo et al; licensee BioMed Central Ltd. 2013 Takatalo et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b580t-9692947f5d0ec7a0d573bcfef4b0445af1b1c72ae06208d0960c693a2df32b9f3</citedby><cites>FETCH-LOGICAL-b580t-9692947f5d0ec7a0d573bcfef4b0445af1b1c72ae06208d0960c693a2df32b9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599904/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1317052699?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23497297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takatalo, Jani</creatorcontrib><creatorcontrib>Karppinen, Jaro</creatorcontrib><creatorcontrib>Taimela, Simo</creatorcontrib><creatorcontrib>Niinimäki, Jaakko</creatorcontrib><creatorcontrib>Laitinen, Jaana</creatorcontrib><creatorcontrib>Blanco Sequeiros, Roberto</creatorcontrib><creatorcontrib>Paananen, Markus</creatorcontrib><creatorcontrib>Remes, Jouko</creatorcontrib><creatorcontrib>Näyhä, Simo</creatorcontrib><creatorcontrib>Tammelin, Tuija</creatorcontrib><creatorcontrib>Korpelainen, Raija</creatorcontrib><creatorcontrib>Tervonen, Osmo</creatorcontrib><title>Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986</title><title>BMC musculoskeletal disorders</title><addtitle>BMC Musculoskelet Disord</addtitle><description>The role of environmental factors in lumbar intervertebral disc degeneration (DD) in young adults is largely unknown. Therefore, we investigated whether body mass index (BMI), smoking, and physical activity are associated with lumbar DD among young adults.
The Oulu Back Study (OBS) is a subpopulation of the 1986 Northern Finland Birth Cohort (NFBC 1986) and it originally included 2,969 children. The OBS subjects received a postal questionnaire, and those who responded (N = 1,987) were invited to the physical examination. The participants (N = 874) were invited to lumbar MRI study. A total of 558 young adults (325 females and 233 males) underwent MRI that used a 1.5-T scanner at the mean age of 21. Each lumbar intervertebral disc was graded as normal (0), mildly (1), moderately (2), or severely (3) degenerated. We calculated a sum score of the lumbar DD, and analyzed the associations between environmental risk factors (smoking, physical activity and weight-related factors assessed at 16 and 19 years) and DD using ordinal logistic regression, the results being expressed as cumulative odds ratios (COR). All analyses were stratified by gender.
Of the 558 subjects, 256 (46%) had no DD, 117 (21%) had sum score of one, 93 (17%) sum score of two, and 92 (17%) sum score of three or higher. In the multivariate ordinal logistic regression model, BMI at 16 years (highest vs. lowest quartile) was associated with DD sum score among males (COR 2.35; 95% CI 1.19-4.65) but not among females (COR 1.29; 95% CI 0.72-2.32). Smoking of at least four pack-years was associated with DD among males, but not among females (COR 2.41; 95% CI 0.99-5.86 and 1.59; 95% 0.67-3.76, respectively). Self-reported physical activity was not associated with DD.
High BMI at 16 years was associated with lumbar DD at 21 years among young males but not among females. High pack-years of smoking showed a comparable association in males, while physical activity had no association with DD in either gender. These results suggest that environmental factors are associated with DD among young males.</description><subject>Analysis</subject><subject>Body Mass Index</subject><subject>Degeneration (Pathology)</subject><subject>Exercise</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intervertebral Disc Degeneration - diagnosis</subject><subject>Intervertebral Disc Degeneration - epidemiology</subject><subject>Intervertebral disk</subject><subject>Life Style</subject><subject>Logistic Models</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Motor Activity</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Odds Ratio</subject><subject>Physical Examination</subject><subject>Physical Fitness</subject><subject>Physiological aspects</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1471-2474</issn><issn>1471-2474</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFks1u1DAUhSMEoqWwZocssWGT1o6d2GaB1FYtIFWwgbXl34mrxB7spDCPwFvXYcrQQUUoizj3fvfk6hxX1UsEjxFi3QkiFNUNoaRGpGb0UXW4qzy-dz6onuV8DSGiDPOn1UGDCacNp4fVz7NoNmCUOQMfjP0BfAblI2ovJ2vAdz_1YJhHJRMwPmtg7MoGm-TkYygTYBPnsAKXPgSf-6Iz2PwW5FllOa4HC6IDn2KaepvCAg0yGKB8KQAd-9IAeZrL_xFn3fPqiZNDti_u3kfV18uLL-cf6qvP7z-en17VqmVwqnnHG06oaw20mkpoWoqVdtYRBQlppUMKadpIC7sGMgN5B3XHsWyMw43iDh9V77a661mN1mgbpiQHsU5-lGkjovRivxN8L1bxRuCWcw5JETjbCigf_yGw39FxFEsUYominASjReTN3RYpfpttnsRY7LVDccjGOQvEOMWMtoz9H8UlVsI62hb09V_odZxTKHb-omDbdJz_oVYlLuGDi2VNvYiK0xaTblkTF-r4Aao8xo5ex2CdL_W9gZPtgE4x52TdzhIExXJbHzDh1f0odvzv64lvASf05Yk</recordid><startdate>20130311</startdate><enddate>20130311</enddate><creator>Takatalo, Jani</creator><creator>Karppinen, Jaro</creator><creator>Taimela, Simo</creator><creator>Niinimäki, Jaakko</creator><creator>Laitinen, Jaana</creator><creator>Blanco Sequeiros, Roberto</creator><creator>Paananen, Markus</creator><creator>Remes, Jouko</creator><creator>Näyhä, Simo</creator><creator>Tammelin, Tuija</creator><creator>Korpelainen, Raija</creator><creator>Tervonen, Osmo</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130311</creationdate><title>Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986</title><author>Takatalo, Jani ; Karppinen, Jaro ; Taimela, Simo ; Niinimäki, Jaakko ; Laitinen, Jaana ; Blanco Sequeiros, Roberto ; Paananen, Markus ; Remes, Jouko ; Näyhä, Simo ; Tammelin, Tuija ; Korpelainen, Raija ; Tervonen, Osmo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b580t-9692947f5d0ec7a0d573bcfef4b0445af1b1c72ae06208d0960c693a2df32b9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Body Mass Index</topic><topic>Degeneration (Pathology)</topic><topic>Exercise</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intervertebral Disc Degeneration - diagnosis</topic><topic>Intervertebral Disc Degeneration - epidemiology</topic><topic>Intervertebral disk</topic><topic>Life Style</topic><topic>Logistic Models</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Motor Activity</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Odds Ratio</topic><topic>Physical Examination</topic><topic>Physical Fitness</topic><topic>Physiological aspects</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takatalo, Jani</creatorcontrib><creatorcontrib>Karppinen, Jaro</creatorcontrib><creatorcontrib>Taimela, Simo</creatorcontrib><creatorcontrib>Niinimäki, Jaakko</creatorcontrib><creatorcontrib>Laitinen, Jaana</creatorcontrib><creatorcontrib>Blanco Sequeiros, Roberto</creatorcontrib><creatorcontrib>Paananen, Markus</creatorcontrib><creatorcontrib>Remes, Jouko</creatorcontrib><creatorcontrib>Näyhä, Simo</creatorcontrib><creatorcontrib>Tammelin, Tuija</creatorcontrib><creatorcontrib>Korpelainen, Raija</creatorcontrib><creatorcontrib>Tervonen, Osmo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC musculoskeletal disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takatalo, Jani</au><au>Karppinen, Jaro</au><au>Taimela, Simo</au><au>Niinimäki, Jaakko</au><au>Laitinen, Jaana</au><au>Blanco Sequeiros, Roberto</au><au>Paananen, Markus</au><au>Remes, Jouko</au><au>Näyhä, Simo</au><au>Tammelin, Tuija</au><au>Korpelainen, Raija</au><au>Tervonen, Osmo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986</atitle><jtitle>BMC musculoskeletal disorders</jtitle><addtitle>BMC Musculoskelet Disord</addtitle><date>2013-03-11</date><risdate>2013</risdate><volume>14</volume><issue>1</issue><spage>87</spage><epage>87</epage><pages>87-87</pages><artnum>87</artnum><issn>1471-2474</issn><eissn>1471-2474</eissn><abstract>The role of environmental factors in lumbar intervertebral disc degeneration (DD) in young adults is largely unknown. Therefore, we investigated whether body mass index (BMI), smoking, and physical activity are associated with lumbar DD among young adults.
The Oulu Back Study (OBS) is a subpopulation of the 1986 Northern Finland Birth Cohort (NFBC 1986) and it originally included 2,969 children. The OBS subjects received a postal questionnaire, and those who responded (N = 1,987) were invited to the physical examination. The participants (N = 874) were invited to lumbar MRI study. A total of 558 young adults (325 females and 233 males) underwent MRI that used a 1.5-T scanner at the mean age of 21. Each lumbar intervertebral disc was graded as normal (0), mildly (1), moderately (2), or severely (3) degenerated. We calculated a sum score of the lumbar DD, and analyzed the associations between environmental risk factors (smoking, physical activity and weight-related factors assessed at 16 and 19 years) and DD using ordinal logistic regression, the results being expressed as cumulative odds ratios (COR). All analyses were stratified by gender.
Of the 558 subjects, 256 (46%) had no DD, 117 (21%) had sum score of one, 93 (17%) sum score of two, and 92 (17%) sum score of three or higher. In the multivariate ordinal logistic regression model, BMI at 16 years (highest vs. lowest quartile) was associated with DD sum score among males (COR 2.35; 95% CI 1.19-4.65) but not among females (COR 1.29; 95% CI 0.72-2.32). Smoking of at least four pack-years was associated with DD among males, but not among females (COR 2.41; 95% CI 0.99-5.86 and 1.59; 95% 0.67-3.76, respectively). Self-reported physical activity was not associated with DD.
High BMI at 16 years was associated with lumbar DD at 21 years among young males but not among females. High pack-years of smoking showed a comparable association in males, while physical activity had no association with DD in either gender. These results suggest that environmental factors are associated with DD among young males.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23497297</pmid><doi>10.1186/1471-2474-14-87</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Analysis Body Mass Index Degeneration (Pathology) Exercise Female Finland - epidemiology Health aspects Humans Intervertebral Disc Degeneration - diagnosis Intervertebral Disc Degeneration - epidemiology Intervertebral disk Life Style Logistic Models Lumbar Vertebrae - pathology Magnetic Resonance Imaging Male Medical research Motor Activity NMR Nuclear magnetic resonance Odds Ratio Physical Examination Physical Fitness Physiological aspects Risk Factors Sex Factors Smoking - adverse effects Smoking - epidemiology Studies Surveys and Questionnaires Young Adult |
title | Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986 |
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