Antioxidant and Hepatoprotective Properties of Tofu (Curdle Soymilk) against Acetaminophen-Induced Liver Damage in Rats

The antioxidant and hepatoprotective properties of tofu using acetaminophen to induce liver damage in albino rats were evaluated. Tofus were prepared using calcium chloride, alum, and steep water as coagulants. The polyphenols of tofu were extracted and their antioxidant properties were determined....

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Bibliographic Details
Published in:Biotechnology Research International 2013-01, Vol.2013 (2013), p.17-23
Main Authors: Yakubu, Ndatsu, Olalekan, Amuzat Aliyu, Oboh, Ganiyu
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Chemical properties
Cholesterol
Colleges & universities
Diet
Liver diseases
Soybeans
Tofu
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Summary:The antioxidant and hepatoprotective properties of tofu using acetaminophen to induce liver damage in albino rats were evaluated. Tofus were prepared using calcium chloride, alum, and steep water as coagulants. The polyphenols of tofu were extracted and their antioxidant properties were determined. The weight gain and feed intake of the rats were measured. The analysis of serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities and the concentrations of albumin, total protein, cholesterol, and bilirubin were analyzed. The result reveals that the antioxidant property of both soluble and bound polyphenolic extracts was significantly higher in all tofus, but the steep water coagulated tofu was recorded higher. Rats fed with various tofus and acetaminophen had their serum ALP, ALT, AST, and LDH activities; total cholesterol; and bilirubin levels significantly (P
ISSN:2090-3138
2090-3146
2090-3146
DOI:10.1155/2013/230142