Quantitative Pharmacology: An introduction to integrative pharmacokinetic‐pharmacodynamic analysis

In “Quantitative Pharmacology,” Gabrielsson and Hjorth explain that it is the integration of key time‐dependent processes in vivo: pharmacokinetics (PK; absorption; distribution to target and other sites; binding to target and nonspecific entities; elimination) and pharmacodynamics (PD; target bindi...

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Bibliographic Details
Published in:CPT: pharmacometrics and systems pharmacology 2012-12, Vol.1 (12), p.1-2
Main Author: Lowe, PJ
Format: Article
Language:English
Subjects:
Drug dosages
Pharmacodynamics
Pharmacokinetics
Pharmacology
Plasma
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Summary:In “Quantitative Pharmacology,” Gabrielsson and Hjorth explain that it is the integration of key time‐dependent processes in vivo: pharmacokinetics (PK; absorption; distribution to target and other sites; binding to target and nonspecific entities; elimination) and pharmacodynamics (PD; target binding driving system–related responses, whether in parallel or a causal series). [...]it is the trade off between potency (e.g., Ki), the fraction unbound (fu), and CL which must be optimized. [...]in “Inter‐species scaling,” information is integrated to scale preclinical PKPD models to man.
ISSN:2163-8306
2163-8306
DOI:10.1038/psp.2012.19