Exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats

Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and cast...

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Bibliographic Details
Published in:Iranian biomedical journal 2013, Vol.17 (1), p.49-53
Main Authors: Yousofvand, Namdar, Zarei, Fatemeh, Ghanbari, Ali
Format: Article
Language:English
Subjects:
Animals
Chromium - blood
Finasteride - administration & dosage
Finasteride - pharmacology
Insulin - blood
Male
Orchiectomy
Original
Rats
Rats, Wistar
Testosterone - administration & dosage
Testosterone - blood
Testosterone - pharmacology
Trace Elements - blood
Zinc - blood
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Summary:Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Male adult rats (n = 32) were divided into 4 groups (n = 8). Group 1, control; Group 2, castration, castration was done at the first day of the study; Group 3, finasteride (20 mg/kg/day, dissolved in drinking water) and Group 4, testosterone (5 mg/kg/day, i.p.). At the end of the period of the study (35 days), serum testosterone, insulin, zinc and chromium levels were determined in the blood samples collected directly from the right atrium of the heart of the animals. The data indicated that the serum levels of testosterone, insulin and zinc were significantly increased (P
ISSN:1028-852X
2008-823X
DOI:10.6091/ibj.1110.2012